Objective: Funnel plots (plots of effect estimates against sample size) may be useful to detect bias in meta-analyses that were later contradicted by large trials. We examined whether a simple test of asymmetry of funnel plots predicts discordance of results when meta-analyses are compared to large trials, and we assessed the prevalence of bias in published meta-analyses. Design: Medline search to identify pairs consisting of a meta-analysis and a single large trial (concordance of results was assumed if effects were in the same direction and the meta-analytic estimate was within 30% of the trial); analysis of funnel plots from 37 meta-analyses identified from a hand search of four leading general medicine journals 1993-6 and 38 meta-analyses from the second 1996 issue of the Cochrane Database of Systematic Reviews . Main outcome measure: Degree of funnel plot asymmetry as measured by the intercept from regression of standard normal deviates against precision. Results: In the eight pairs of meta-analysis and large trial that were identified (five from cardiovascular medicine, one from diabetic medicine, one from geriatric medicine, one from perinatal medicine) there were four concordant and four discordant pairs. In all cases discordance was due to meta-analyses showing larger effects. Funnel plot asymmetry was present in three out of four discordant pairs but in none of concordant pairs. In 14 (38%) journal meta-analyses and 5 (13%) Cochrane reviews, funnel plot asymmetry indicated that there was bias. Conclusions: A simple analysis of funnel plots provides a useful test for the likely presence of bias in meta-analyses, but as the capacity to detect bias will be limited when meta-analyses are based on a limited number of small trials the results from such analyses should be treated with considerable caution. Key messages Systematic reviews of randomised trials are the best strategy for appraising evidence; however, the findings of some meta-analyses were later contradicted by large trials Funnel plots, plots of the trials9 effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials Funnel plot asymmetry was found in 38% of meta-analyses published in leading general medicine journals and in 13% of reviews from the Cochrane Database of Systematic Reviews Critical examination of systematic reviews for publication and related biases should be considered a routine procedure

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Bias in meta-analysis detected by a simple, graphical test

物件導向軟體之架構(Object-Oriented Software Construction)探討

From the Publisher:
Written by the inventors of the technology, The Java(tm) Language Specification, Second Edition is the definitive technical reference for the Java(tm) programming language If you want to know the precise meaning of the language's constructs, this is the source for you 
The book provides complete, accurate, and detailed coverage of the syntax and semantics of the Java programming language It describes all aspects of the language, including the semantics of all types, statements, and expressions, as well as threads and binary compatibility

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The Java Language Specification

We have found many programming problems for which neither procedural nor object-oriented programming techniques are sufficient to clearly capture some of the important design decisions the program must implement. This forces the implementation of those design decisions to be scattered throughout the code, resulting in “tangled” code that is excessively difficult to develop and maintain. We present an analysis of why certain design decisions have been so difficult to clearly capture in actual code. We call the properties these decisions address aspects, and show that the reason they have been hard to capture is that they cross-cut the system's basic functionality. We present the basis for a new programming technique, called aspect-oriented programming, that makes it possible to clearly express programs involving such aspects, including appropriate isolation, composition and reuse of the aspect code. The discussion is rooted in systems we have built using aspect-oriented programming.

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Aspect-Oriented Programming

Aspect-oriented programming (AOP) is a technique for improving separation of concerns in software design and implementation. AOP works by providing explicit mechanisms for capturing the structure of crosscutting concerns. This tutorial shows how to use AOP to implement crosscutting conerns in a concise modular way. It works with AspectJ, a seamless aspect-oriented extension to the Java(tm) programming language, and with AspectC, an aspect-oriented extension to C in the style of AspectJ. It also includes a description of their underlying model, in terms of which a wide range of AOP languages can be understood.

Aspect-oriented programming

Most approaches to programming language extensibility have worked by pairing syntactic extension with semantic extension. We present an approach that works through a combination of presentation extension and semantic extension. We also present an architecture for this approach, an Eclipse-based implementation targeting the Java programming language, and examples that show how presentation extension, both with and without semantic extension, can make programs more expressive.

Expressive programs through presentation extension

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Aspect-Oriented Programming The Fun Has Just Begun

The implementor of an operating system service faces inherent dilemmas in choosing implementation strategies. A new approach to operating system design is emerging in which, rather than attempting to hide these dilemmas, they are exposed to clients, using a meta-protocols. Object-oriented programming techniques play an important role in enabling meta-protocols to expose these dilemmas to the client in a principled and modular fashion. >

Operating systems: why object-oriented?

The photocopier is one of the most complex machines because xerography involves many types of physical phenomena. ARIA is a qualitative simulation of xerography that is intended to teach technicians the reasons behind some of the subtle problems that occur in copiers. This effort to model xerography exposed shortcomings in the techniques of qualitative modeling as applied to complex systems and helped to better understand the impact of certain basic modeling decisions.

Issues in the pragmatics of qualitative modeling: lessons learned from a xerographics project

A partial evaluator, or pre-compiler, for a computer program enables a user to provide, at suitable places within a program, language constructs which cause certain expressions within the program to be evaluated at runtime or at partial evaluation time. These language constructs can be used to shorten runtime, such as by avoiding unnecessary duplication of code at runtime.

Gregor Kiczales

Papers

Expressive programs through presentation extension

Aspect-Oriented Programming The Fun Has Just Begun

Operating systems: why object-oriented?

Issues in the pragmatics of qualitative modeling: lessons learned from a xerographics project

Software constructs that facilitate partial evaluation of source code