G
Gregory J. Gores
Researcher at Mayo Clinic
Publications - 787
Citations - 76060
Gregory J. Gores is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Medicine & Apoptosis. The author has an hindex of 141, co-authored 686 publications receiving 66269 citations. Previous affiliations of Gregory J. Gores include University of Florida & University of Rochester.
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A global view of hepatocellular carcinoma: trends, risk, prevention and management.
TL;DR: Together, rational deployment of prevention, attainment of global goals for viral hepatitis eradication, and improvements in HCC surveillance and therapy hold promise for achieving a substantial reduction in the worldwide HCC burden within the next few decades.
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Design and Endpoints of Clinical Trials in Hepatocellular Carcinoma
Josep M. Llovet,Adrian M. Di Bisceglie,Jordi Bruix,Barnett S. Kramer,Riccardo Lencioni,Andrew X. Zhu,Morris Sherman,Myron Schwartz,Michael Lotze,Jayant A. Talwalkar,Gregory J. Gores +10 more
TL;DR: These guidelines provide a common framework for designing trials to facilitate comparability of results, and randomized phase 2 trials with a time-to-event primary endpoint, such as time to progression, are pivotal in clinical research on HCC.
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Mechanisms of Hepatotoxicity
Hartmut Jaeschke,Gregory J. Gores,Arthur I. Cederbaum,Jack A. Hinson,Dominique Pessayre,John J. Lemasters +5 more
TL;DR: This review addresses recent advances in specific mechanisms of hepatotoxicity, including inducible nitric oxide synthase knockout mice, where nitration is prevented, but unscavenged superoxide production then causes toxic lipid peroxidation to occur instead.
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Hepatocellular carcinoma: clinical frontiers and perspectives
TL;DR: While several trials have failed to improve the benefits of established therapies, studies assessing the sequential or combined application of those already known to be beneficial are needed to help explain the failure of prior studies.
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Diagnosis and Management of Primary Sclerosing Cholangitis
Roger W. Chapman,Johan Fevery,Anthony N. Kalloo,David M. Nagorney,Kirsten Muri Boberg,Benjamin L. Shneider,Gregory J. Gores +6 more
TL;DR: Intended for use by physicians, these recommendations suggest preferred approaches to the diagnostic, therapeutic and preventative aspects of care that are intended to be flexible, in contrast to standards of care, which are inflexible policies to be followed in every case.