Gregory M. Lanza

TL;DR: These data provide the first in vivo demonstration of a site-specific ultrasonic contrast agent and have potential for improved sensitivity and specificity for noninvasive diagnosis of thrombi and other pathological diseases.

TL;DR: The recent emergence of “molecular imaging” as an integrated discipline in academic medical centers has set the stage for an evolutionary leap in diagnostic imaging and therapy, and 5 action items critical to achieving these goals are identified.

TL;DR: It is demonstrated that this novel nanoemulsion can infiltrate into arterial walls after balloon injury and localize the expression of overstretch-induced tissue factor within pig carotid arteries.

TL;DR: In this article, a ligand-based binding of lipid encapsulated particles to molecular epitopes on a surface in vivo or in vitro comprises sequentially administering (a) a site-specific ligand activated with a biotin activating agent; (b) an avidin activating agent, whereby the ligand is conjugated to the particles through a avidin-biotin interaction and the resulting conjugate is bound to the molecular epitope on such surface.

TL;DR: In this paper, a method for the delivery of a therapeutic agent using lipid-encapsulated particles containing the therapeutic agent and ultrasound energy was proposed, where the emulsion is coupled a targeting ligand and comprises a therapeutic agents.