https://www.scielosp.org/pdf/gs/2011.v25n4/282-289/en

Adherence to highly active antiretroviral therapy in Spain: A meta-analysis

Objective quantification of adherence to prophylaxis in haemophilia patients aged 12 to 25years and its potential association with bleeding episodes.

Adherencia subóptima al tratamiento en la esclerosis múltiple

http://www.grupoaulamedica.com/fh/pdf/407.pdf

Una década del grupo VIH-SEFH: evaluando el progreso, identificando obstáculos y renovando el compromiso

SummaryWhat is known and objective
Antiretroviral treatment (ART) is hampered by complicated regimens, high pill burden, drug–drug interactions, and frequent short- and long-term adverse effects, leading to decreased adherence. Over recent years, considerable effort has been directed at developing regimens that are less burdening. We undertook a 7-year retrospective study of the records of 264 HIV-infected subjects enrolled in a pharmaceutical care programme to document the progress made and to study the influence of the number of ART pills and doses on the level of treatment adherence.

Methods
Antiretroviral dispensing records were analysed for the number of pills and doses administered and the ART adherence rate estimated.

Results and discussion
In 2005, the patients took a mean of 6·2 pills daily (CI 95%: 5·9–6·6), and 92·9% of them were on a twice-a-day (BID) dosage regimen. By 2012, the mean number of pills was reduced to 4·1 (CI 95%: 3·8–4·4), and only 50·9% were on a BID regimen. No statistically significant relation was observed between number of daily pills and doses and ART adherence reached by the patients in any of the analyses performed.

What is new and conclusions
There has been a continuous reduction in the number of pills and doses of antiretrovirals taken by individual patients over the last 7 years due largely to the introduction of improved treatments and regimens. More daily pills or doses was not associated with worse ART adherence in our pharmaceutical care programme.

/pdf/influence-of-the-number-of-daily-pills-and-doses-on-49p8zyegt3.pdf

Grupo de Estudio del Sida

Papers

Mejorar la adherencia al tratamiento antirretroviral. Recomendaciones de la SPNS/SEFH/GESIDA