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Showing papers by "Guillermo Díaz-Araya published in 2014"

Journal Article•DOI•
Angiotensin-(1–9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis

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María Paz Ocaranza1, Jackeline Moya, Victor Barrientos, Rodrigo Alzamora, Daniel Hevia, Cristobal Morales, Melissa Pinto, Nicolás Escudero, Lorena García, Ulises Novoa, Pedro Ayala, Guillermo Díaz-Araya, Iván Godoy, Mario Chiong, Sergio Lavandero, Jorge E. Jalil, Luis Michea •
University of Texas Southwestern Medical Center1
01 Apr 2014-Journal of Hypertension
TL;DR: Angiotensin-(1–9) reduces hypertension, ameliorates structural alterations (hypertrophy and fibrosis), oxidative stress in the heart and aorta and improves cardiac and endothelial function in hypertensive rats.
Abstract: Background:Little is known about the biological effects of angiotensin-(1–9), but available evidence shows that angiotensin-(1–9) has beneficial effects in preventing/ameliorating cardiovascular remodeling.Objective:In this study, we evaluated whether angiotensin-(1–9) decreases hypertension and rev

79 citations

Journal Article•DOI•
4-Phenylbutyric acid prevent cytotoxicity induced by thapsigargin in rat cardiac fibroblast

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Claudio Humeres1, J. Montenegro1, M. Varela1, Pedro Ayala1, Raúl Vivar1, Alan Letelier1, Ivonne Olmedo1, Mabel Catalán1, C. Rivas1, P. Baeza1, Claudia Muñoz1, Lorena García1, Sergio Lavandero1, Guillermo Díaz-Araya1 •
University of Chile1
01 Dec 2014-Toxicology in Vitro
TL;DR: In CF, thapsigargin triggered the unfolded protein response detected by early increases in ATF4, CHOP, PDI and BIP protein levels as well as, the accumulation of intracellular procollagen.

22 citations