Günter Dörner

TL;DR: In this paper, the authors investigated long-term consequences of early postnatal overfeeding in Wistar rats and found that neonatally acquired persisting malformation of hypothalamic galaninergic neurons, induced by early overfeeding and hyperinsulinism, might promote the development of overweight and syndrome X-like alterations during life.

TL;DR: It is suggested once more that hyperinsulinism during brain differentiation, in the present experiment induced by early postnatal overnutrition, may represent a predisposing factor for the development of obesity, of increased diabetes susceptibility and also of increased cardiovascular risk in later life.

TL;DR: A pathogenetic role of fetal and neonatal hyperinsulinism for the development of IGT in both groups of infants of diabetic mothers is suggested, in particular for early induction of insulin resistance in the offspring of mothers with pregestational IDDM.

TL;DR: Infants of mothers with diabetes during pregnancy are predisposed to develop overweight and obesity during childhood, and alterations seem to be related to insulin and relative body weight at birth.

TL;DR: In this article, the authors investigated consequences of early postnatal overnutrition, as compared to normo-and undernutrition, on NPY within the arcuate nucleus and paraventricular nucleus (PVN).