Guoying Jin

TL;DR: Mechanistic insights are provided into the regulation of FEZF1-AS1 on both STAT3 signaling and glycolysis by binding PKM2 and increasing its stability by binding and increasing the stability of pyruvate kinase 2.

TL;DR: This study demonstrates that a panel of serum exosomal miRNAs containingmiR-21-5p, miR-1246, mi-1229-5 p and mi-96- 5p could significantly distinguish the chemotherapy-resistant group from advanced colorectal cancer patients.

TL;DR: It is confirmed that exosomal miR‐204‐5p could efficiently inhibit cancer cell proliferation, induce apoptosis and increase chemosensitivity by specifically suppressing the target genes of miR •204‐ 5p in human cancer cells.

TL;DR: These studies demonstrate that long noncoding RNA (lncRNA) plays an important role in the occurrence and development of human cancer and promotes cell proliferation through SNHG15/miR‐338‐3p/FOS‐RAB14 axis in CRC.

TL;DR: It is suggested that inhibiting the secretion of specific sEV-miRNAs from CRC and targeting PD-L1 in TAMs may serve as novel methods for CRC treatment as well as a sensitization method for anti-PD- L1 therapy in CRC.