Showing papers by "Gustavo Kourí published in 1984"
TL;DR: Clinical and serological studies were carried out on 114 patients admitted to hospital in Havana, Cuba with Dengue Haemorrhagic Fever and Dengue Shock Syndrome, finding 95% of the cases could be explained on the basis of the secondary infection hypothesis.
Abstract: Clinical and serological studies were carried out on 114 patients admitted to hospital in Havana, Cuba with Dengue Haemorrhagic Fever and Dengue Shock Syndrome (DHF/DSS). Serological confirmation of dengue was obtained in 90% of cases, with 5% of cases primary and 95% secondary. Fever, haemorrhagic manifestations, vomiting and headache were the most frequent signs and symptoms. Among haemorrhagic manifestations, petechiae and vaginal bleeding were reported in a larger number of patients. 21 patients presented shock and, of these, 20 were secondary infections. The disease appeared more frequently in white persons and in women. The aetiopathogenicity of the syndromes is discussed. 95% of the cases could be explained on the basis of the secondary infection hypothesis.
70 citations
01 Jan 1984
TL;DR: In 1954 the first known epidemic of dengue hemorrhagic fever (DHF) struck the Philippines; depending upon the promptness with which cases were hospitalized, between 5% and 15% of the patients died.
Abstract: In 1954 the first known epidemic of dengue hemorrhagic fever (DHF) struck the Philippines; depending upon the promptness with which cases were hospitalized, between 5% and 15% of the patients died. Since then DHF has constituted a significant health problem for the countries of Southeast Asia and the Western Pacific (1, 2). In 1977 dengue1 virus, which had not previously been reported in the Caribbean area, entered that area and Cuba (3). giving rise to the first cases of classic dengue fever reported in Cuba since 1945 (4) and causing a massive dengue epidemic throughout the island. The &us, identified both serologically and by direct isolation, circulated widely among the Cuban population during 1977 and 1978 (5), and until 1981 maintained a more limited circulation-producing a small number of serologically confirmed cases (6). During this period only sporadic cases of hemorrhagic dengue were reported, either in Cuba or elsewhere in the Caribbean area, despite the combined presence of dengue serotypes 1, 2, and 3 within the area (3, 7, 8). Toward the end of May 198 1, cases of illness were reported in the city of Havana involving a febrile syndrome accompanied in some cases by hemorrhage (of various types and degrees of
52 citations
TL;DR: Serological studies by the haemagglutinin inhibition test to confirm a clinical diagnosis of dengue were done on 406 patients during the d Dengue 2 epidemic in Cuba in 1981, finding the white race and female sex were found to predominate in the positive cases.
Abstract: Serological studies by the haemagglutinin inhibition test to confirm a clinical diagnosis of dengue were done on 406 patients during the dengue 2 epidemic in Cuba in 1981. 49% of the cases were serologically positive; of these 64% was classified as primary and 36% as secondary. The frequency of symptoms is described: the most frequent were fever, headache, malaise and vomiting. Haemorrhagic manifestations predominated significantly in the secondary cases. The white race and female sex were found to predominate in the positive cases.
42 citations