H
H. Dutertre-Catella
Researcher at Paris Descartes University
Publications - 10
Citations - 108
H. Dutertre-Catella is an academic researcher from Paris Descartes University. The author has contributed to research in topics: Nephrotoxicity & Cyclosporin a. The author has an hindex of 6, co-authored 10 publications receiving 105 citations.
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Journal ArticleDOI
Modulation of energy status and cytotoxicity induced by FK506 and cyclosporin A in a renal epithelial cell line.
F. Massicot,C. Martin,H. Dutertre-Catella,S. Ellouk-Achard,C. Pham-Huy,M. Thevenin,P. Rucay,Jean-Michel Warnet,J. R. Claude +8 more
TL;DR: By preserving energy status, FK506 leads to fewer metabolic disturbances than CsA in the renal epithelial cell line LLC-PK1, demonstrating a minor potential nephrotoxicity.
Journal ArticleDOI
Protective Effect of Nifedipine Against Cytotoxicity and Intracellular Calcium Alterations Induced by Acetaminophen in Rat Hepatocyte Cultures
TL;DR: It can be concluded that, in vitro conditions, nifedipine pretreatment exhibits a preventive effect against acetaminophen hepatocyte injury.
Book ChapterDOI
Ex Vivo and in Vitro Models in Acetaminophen Hepatotoxicity Studies. Relationship between Glutathione Depletion, Oxidative Stress and Disturbances in Calcium Homeostasis and Energy Metabolism
S. Ellouk-Achard,V. Levresse,C. Martin,C. Pham-Huy,H. Dutertre-Catella,M. Thevenin,Jean-Michel Warnet,J. R. Claude +7 more
TL;DR: The hepatotoxicity of acetaminophen seems to be linked to several biochemical perturbations such as glutathione depletion, oxidative stress, Ca2+ homeostasis disturbances and/or changes in energy metabolism.
Journal ArticleDOI
Implication of CYP 3A in the toxicity of cyclosporin G (CsG), cyclosporin A (CsA) and FK506 on rat hepatocytes in primary culture
S. Ellouk-Achard,C. Martin,C. Pham-Huy,H.T. Duc,M. Thevenin,H. Dutertre-Catella,Jean-Michel Warnet,J. R. Claude +7 more
TL;DR: The results show that the toxicity of the three drugs in rat hepatocytes is dependent on CYP 3A induction: increased for FK506, decreased for CsA and CsG, indicating that Csg metabolites are also less toxic than the parent drug.
Journal ArticleDOI
Effects of cyclosporin on kidney glutathione metabolism and cytochrome P-450 in the rabbit: possible implication of eicosanoid metabolism.
TL;DR: The mechanism of CsA nephrotoxicity is to be related to a cytochrome P-450 induction, which could induce the observed impairments in renal glutathione metabolism and Na+K(+)-ATPase activity, via a possible increase in eicosanoid metabolism.