Showing papers by "Hainv Gao published in 2017"
TL;DR: The application of Ad5-EBOV demonstrated safe in Africans in China and a specific GP antibody and T-cell response could occur 14 d after the first immunization, which provides a reliable basis to proceed with trials in Africa.
Abstract: Background: To determine the safety and immunogenicity of a novel recombinant adenovirus type 5 vector based Ebola virus disease vaccine (Ad5-EBOV) in Africans in China.Methods: A phase 1, dose-esc...
29 citations
TL;DR: The epidemiology of HBV infection is location dependent, and the prevalence ofHBV infection in the mountainous regions is higher than the national levels, which represents a main factor for continuous HBV transmission.
Abstract: The overall prevalence of hepatitis B virus (HBV) infection in China is declining. The purpose of this study was to use a community-based epidemiological study to update the infection status of hepatitis B virus (HBV) in mountainous regions of China, and to evaluate the impact of the Expanded Program of Immunization (EPI) on HBV transmission. In total, 10,383 participants were selected by multi-stage stratified random cluster sampling in two mountainous regions, Xianju and Anji, in Zhejiang province, China. The positive rates of hepatitis B virus surface antigen (HBsAg), anti-HBV core antigen (anti-HBc), and anti-HBV surface antigen (anti-HBs) were 9.5%, 33.9%, and 51.0%, respectively. Positive HBV markers were more frequently detected in males than in females (P 38 IU/L) in 15.3% of the HBsAg-positive and 6.3% of the HBsAg-negative subjects. The α-fetoprotein (AFP) level was elevated in 0.8% of the HBsAg-positive participants who were older than 30 years old. The epidemiology of HBV infection is location dependent. The prevalence of HBV infection in the mountainous regions is higher than the national levels. Moreover, HBV infection in women of childbearing age is up to 10%, which represents a main factor for continuous HBV transmission.
13 citations
TL;DR: Investigation of correlation between quantitative hepatitis B e antigen (HBeAg) and hepatitis B virus (HBV) DNA levels and whether semiquantitative measurement of HBeAg can indicate the extent of HBV replication in H beAg-positive subjects in the immune tolerant phase found it correlated well with the HBV DNA level.
13 citations