H
Haitao Yan
Publications - 18
Citations - 234
Haitao Yan is an academic researcher. The author has contributed to research in topics: Receptor & Gating. The author has an hindex of 8, co-authored 16 publications receiving 192 citations.
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Journal ArticleDOI
External Ba2+ Block of the Two-pore Domain Potassium Channel TREK-1 Defines Conformational Transition in Its Selectivity Filter
Xiao-Yun Ma,Jinmei Yu,Shuzhuo Zhang,Xiao-Yan Liu,Bao-Hong Wu,Xiaoli Wei,Jia-Qing Yan,Hong-Liang Sun,Haitao Yan,Jian-Quan Zheng +9 more
TL;DR: It was found that Ba2+ blocked the TREK-1 channel in a concentration- and time-dependent manner and the N-terminal truncated isoform (ΔN41), a product derived from alternative translation initiation, was identified as a constitutively nonconductive variant.
Journal ArticleDOI
Involvement of HCN Channel in Muscarinic Inhibitory Action on Tonic Firing of Dorsolateral Striatal Cholinergic Interneurons
Zhe Zhao,Kang Zhang,Xiaoyan Liu,Haitao Yan,Xiao-Yun Ma,Shuzhuo Zhang,Jian-Quan Zheng,Liyun Wang,Xiaoli Wei +8 more
TL;DR: It is reported that muscarinic ACh receptor (M receptor) agonists, ACh and Oxotremorine (OXO-M), decreased the firing frequency of ChIs by blocking the hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.
Journal ArticleDOI
Allosteric coupling between proximal C-terminus and selectivity filter is facilitated by the movement of transmembrane segment 4 in TREK-2 channel.
Ren-Gong Zhuo,Peng Peng,Xiao-Yan Liu,Haitao Yan,Jiang-Ping Xu,Jian-Quan Zheng,Xiaoli Wei,Xiao-Yun Ma +7 more
TL;DR: The findings uncover the unique gating properties of TREK-2, and elucidate the mechanisms for how the extracellular and intracellular stimuli harness the pore gating allosterically.
Journal ArticleDOI
Sigma-1 Receptor Plays a Negative Modulation on N-type Calcium Channel
TL;DR: The results revealed that the sigma-1 receptors played a negative modulation on N-type Ca2+ channels and probably involved a chaperone-mediated direct interaction and agonist-induced conformational changes in the receptor-channel complexes on the cell surface.
Journal ArticleDOI
A novel muscarinic antagonist R2HBJJ inhibits non-small cell lung cancer cell growth and arrests the cell cycle in G0/G1.
Hua Nan,Xiaoli Wei,Xiaoyan Liu,Xiao-Yun Ma,He Xinhua,Ren-Gong Zhuo,Zhe Zhao,Liyun Wang,Haitao Yan,Bohua Zhong,Jian-Quan Zheng +10 more
TL;DR: R2HBJJ, as a novel mAChRs antagonist, can block the local cholinergic loop by antagonizing predominantly M3 receptors and inhibit NSCLC cell growth, which suggest that M3 receptor antagonist might be a potential chemotherapeutic regimen forNSCLC.