H
Hajime Hosoi
Researcher at Kyoto Prefectural University of Medicine
Publications - 213
Citations - 5822
Hajime Hosoi is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Rhabdomyosarcoma & Neuroblastoma. The author has an hindex of 34, co-authored 199 publications receiving 5162 citations. Previous affiliations of Hajime Hosoi include St. Jude Children's Research Hospital.
Papers
More filters
Journal ArticleDOI
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
Gregory J. Brunn,Christine C. Hudson,Aleksandar Sekulic,Aleksandar Sekulic,Aleksandar Sekulic,Josie M. Williams,Hajime Hosoi,Peter J. Houghton,John C. Lawrence,Robert T. Abraham +9 more
TL;DR: A role for mTOR in translational control is defined and further insights into the mechanism whereby rapamycin inhibits G1-phase progression in mammalian cells are offered.
Journal Article
Rapamycin Causes Poorly Reversible Inhibition of mTOR and Induces p53-independent Apoptosis in Human Rhabdomyosarcoma Cells
Hajime Hosoi,Michael B. Dilling,Takuma Shikata,Linda N. Liu,Lili Shu,Richard A. Ashmun,Glen S. Germain,Robert T. Abraham,Peter J. Houghton +8 more
TL;DR: This work reports that rapamycin, a specific inhibitor of mTOR kinase, induces G1 cell cycle arrest and apoptosis in two rhabdomyosarcoma cell lines (Rh1 and Rh30) under conditions of autocrine cell growth, and is the first to indicate thatRapamycin-induced apoptosis is mediated by inhibition of m TOR.
Journal Article
PPM1D is a potential target for 17q gain in neuroblastoma
Fumiko Saito-Ohara,Issei Imoto,Jun Inoue,Hajime Hosoi,Akira Nakagawara,Tohru Sugimoto,Johji Inazawa +6 more
TL;DR: The results indicate that PPM1D is the most likely target of the 17q23 gain/amplification in NB tumors and may have an important role in the pathogenesis of this disease.
Journal ArticleDOI
Amino acid-dependent control of p70(s6k). Involvement of tRNA aminoacylation in the regulation.
Yasuhiko Iiboshi,Philip J. Papst,Hideki Kawasome,Hajime Hosoi,Robert T. Abraham,Peter J. Houghton,Naohiro Terada +6 more
TL;DR: In this article, the authors investigated the role of amino acid concentration in the activation of p70s6k and other growth-related protein kinases in human T-lymphoblastoid cells and found that amino acid-induced p70-6k activation was completely inhibited by rapamycin but only partially inhibited by wortmannin.
Journal ArticleDOI
Studies on the Mechanism of Resistance to Rapamycin in Human Cancer Cells
Hajime Hosoi,Michael B. Dilling,Linda N. Liu,Mary K. Danks,Takuma Shikata,Aleksander Sekulic,Robert T. Abraham,John C. Lawrence,Peter J. Houghton +8 more
TL;DR: It is shown that some cell lines derived from childhood tumors are highly sensitive to growth inhibition by rapamycin, whereas others have high intrinsic resistance (>1000-fold).