H
Hamish R. Michie
Researcher at Brigham and Women's Hospital
Publications - 12
Citations - 3117
Hamish R. Michie is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Cyclooxygenase pathway & Tumor necrosis factor alpha. The author has an hindex of 11, co-authored 12 publications receiving 3089 citations. Previous affiliations of Hamish R. Michie include Harvard University.
Papers
More filters
Journal ArticleDOI
Detection of circulating tumor necrosis factor after endotoxin administration.
Hamish R. Michie,Kirk R. Manogue,David R. Spriggs,Arthur Revhaug,S. T. O'Dwyer,Charles A. Dinarello,Anthony Cerami,Sheldon M. Wolff,Douglas W. Wilmore +8 more
TL;DR: It is concluded that the response to endotoxin is associated with a brief pulse of circulating tumor necrosis factor and that the resultant responses are effected through the cyclooxygenase pathway.
Journal Article
Tumor necrosis factor and endotoxin induce similar metabolic responses in human beings.
Hamish R. Michie,David R. Spriggs,Kirk R. Manogue,Matthew L. Sherman,Arthur Revhaug,S. T. O'Dwyer,K A Arthur,Charles A. Dinarello,Anthony Cerami,Sheldon M. Wolff +9 more
TL;DR: TNF may represent the primary afferent signal that initiates many of the metabolic responses associated with sepsis and endotoxemia.
Journal ArticleDOI
Recombinant Human Tumor Necrosis Factor Administered as a 24-Hour Intravenous Infusion. A Phase I and Pharmacologic Study
David R. Spriggs,Matthew L. Sherman,Hamish R. Michie,Kristina A. Arthur,K Imamura,Douglas W. Wilmore,Emil Frei,Donald Kufe +7 more
TL;DR: The 24-hour infusions of rH-TNF were associated with significant decreases in serum cholesterol and high-density lipoprotein levels and Pharmacokinetic studies using an enzyme-linked immunosorbent assay demonstrated peak plasma rhTNF levels of 90-900 pg/mL, despite continuous infusion, no steady-state level was achieved.
Journal ArticleDOI
A Single Dose of Endotoxin Increases Intestinal Permeability in Healthy Humans
S. T. O'Dwyer,Hamish R. Michie,Thomas R. Ziegler,Arthur Revhaug,Robert J. Smith,Douglas W. Wilmore +5 more
TL;DR: It is suggested that a brief exposure to circulating endotoxin increases the permeability of the normal gut, consistent with the hypothesis that during critical illness, prolonged or repeated exposure to systemic endotoxins or associated cytokines may significantly compromise the integrity of the gastrointestinal mucosal barrier.
Journal ArticleDOI
Inhibition of Cyclo-oxygenase Attenuates the Metabolic Response to Endotoxin in Humans
Arthur Revhaug,Hamish R. Michie,James McK. Manson,James M. Watters,Charles A. Dinarello,Sheldon M. Wolff,Douglas W. Wilmore +6 more
TL;DR: Data indicate that activation of the cyclooxygenase pathway is necessary to produce many of the metabolic changes observed during critical illness, including weight loss, hypermetabolism, and accelerated proteolysis.