H
Hannah C. Johnsen
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 3
Citations - 609
Hannah C. Johnsen is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Cancer & Exome. The author has an hindex of 2, co-authored 3 publications receiving 412 citations.
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Journal ArticleDOI
Prospective Comprehensive Molecular Characterization of Lung Adenocarcinomas for Efficient Patient Matching to Approved and Emerging Therapies.
Emmet Jordan,Hyunjae R. Kim,Maria E. Arcila,David Barron,Debyani Chakravarty,Jianjiong Gao,Matthew T. Chang,Andy Ni,Ritika Kundra,Philip Jonsson,Gowtham Jayakumaran,Sizhi Paul Gao,Hannah C. Johnsen,Aphrothiti J. Hanrahan,Ahmet Zehir,Natasha Rekhtman,Michelle S. Ginsberg,Bob T. Li,Helena A. Yu,Paul K. Paik,Alexander Drilon,Matthew D. Hellmann,Dalicia N. Reales,Ryma Benayed,Valerie W. Rusch,Mark G. Kris,Jamie E. Chaft,José Baselga,Barry S. Taylor,Nikolaus Schultz,Charles M. Rudin,David M. Hyman,Michael F. Berger,David B. Solit,Marc Ladanyi,Gregory J. Riely +35 more
TL;DR: The data reported here suggest that broader, early testing for molecular alterations that have not yet been recognized as standard-of-care predictive biomarkers of drug response could accelerate the development of targeted agents for rare mutational events and could result in improved clinical outcomes.
Journal ArticleDOI
3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets.
Jianjiong Gao,Matthew T. Chang,Matthew T. Chang,Hannah C. Johnsen,Sizhi Paul Gao,Brooke E. Sylvester,Selcuk Onur Sumer,Hongxin Zhang,David B. Solit,Barry S. Taylor,Nikolaus Schultz,Chris Sander,Chris Sander +12 more
TL;DR: Analyzing 10,000 tumor exomes, this work identifies more than 3000 rarely mutated residues in proteins as potentially functional and experimentally validate several in RAC1 and MAP2K1.
DatasetDOI
Additional file 5: Table S4. of 3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets
Jianjiong Gao,Matthew T. Chang,Hannah C. Johnsen,Sizhi Gao,Brooke E. Sylvester,Selcuk Onur Sumer,Hongxin Zhang,David B. Solit,Barry S. Taylor,Nikolaus Schultz,Chris Sander +10 more