H
Hannu Kankaanranta
Researcher at University of Gothenburg
Publications - 230
Citations - 7234
Hannu Kankaanranta is an academic researcher from University of Gothenburg. The author has contributed to research in topics: Asthma & Medicine. The author has an hindex of 46, co-authored 184 publications receiving 6315 citations. Previous affiliations of Hannu Kankaanranta include Tampere University of Technology & Imperial College London.
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Journal ArticleDOI
Nitric oxide production and signaling in inflammation.
TL;DR: The present review deals with NO production and signaling in inflammation, especially in relation to human neutrophils and eosinophils, which is recognized as a mediator and regulator of inflammatory responses.
Journal ArticleDOI
Extended exhaled NO measurement differentiates between alveolar and bronchial inflammation.
Lauri Lehtimäki,Hannu Kankaanranta,Seppo Saarelainen,Paula Hahtola,Ritva Järvenpää,Timo Koivula,Väinö Turjanmaa,Eeva Moilanen +7 more
TL;DR: Extended exhaled NO measurement can be used to separately assess alveolar and bronchial inflammation and to assess disease activity/severity in asthma and alveolitis.
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Dexamethasone inhibits inducible nitric-oxide synthase expression and nitric oxide production by destabilizing mRNA in lipopolysaccharide-treated macrophages.
TL;DR: Dexamethasone decreases iNOS-dependent NO production by destabilizing iN OS mRNA in LPS-treated cells by a mechanism that requires de novo protein synthesis.
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Delayed eosinophil apoptosis in asthma
Hannu Kankaanranta,Mark A. Lindsay,Mark A. Giembycz,Xianzhi Zhang,Eeva Moilanen,Peter J. Barnes +5 more
TL;DR: The results suggest that eosinophil apoptosis is delayed in asthma, and the in vitro effects of beta(2)-agonist use might contribute to the prolonged eosInophil survival through inhibition of apoptosis and thus may worsen eos inophilia in asthmatic patients.
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Inhibition by nitric oxide-donors of human polymorphonuclear leucocyte functions.
TL;DR: The results suggest that NO, possibly through increased cyclic GMP, inhibits the activation of human PMNs and may thus act as a local modulator in inflammatory processes.