Showing papers by "Harald Weedon-Fekjær published in 2021"
TL;DR: Despite a high BMI, the cardiovascular risks appeared similar or lower in achondroplasia compared with controls, indicating that other factors might contribute to the increased mortality observed in this condition.
10 citations
TL;DR: The microbiota of the human distal ileum is sparse and differs significantly from the colonic microbiota both quantitatively and by composition, contradict recent metagenomics studies based on samples collected by retrograde colonoscopy and emphasize the crucial importance of adequate sampling techniques.
10 citations
TL;DR: In this paper, the authors investigated the prevalence, severity, and predictive factors of OSA in Norwegian adults with achondroplasia, and found that OSA was found in 59% (29/49) of the participants (95% confidence interval 44 to 73%), of whom 59% had moderate to severe OSA (AHI ≥ 15), and 48% (14/29) were previously undiagnosed.
Abstract: Previous studies have found a high prevalence of obstructive sleep apnea (OSA) in children with achondroplasia, but clinical studies on this complication in adults with achondroplasia are lacking. This population-based, cross-sectional study investigated the prevalence, severity, and predictive factors of OSA in Norwegian adults with achondroplasia. We collected clinical data on 49 participants. Participants without a preexisting diagnosis of OSA had an overnight sleep registration. OSA was defined as an apnea–hypopnea index (AHI) ≥ 5 plus characteristic clinical symptoms, or AHI ≥ 15. We used the Berlin Questionnaire to assess clinical symptoms of OSA. OSA was found in 59% (29/49) of the participants (95% confidence interval 44 to 73%), of whom 59% (17/29) had moderate to severe OSA (AHI ≥ 15), and 48% (14/29) were previously undiagnosed. Variables predictive of OSA were: excessive daytime sleepiness; unrested sleep; loud snoring; observed nocturnal breathing stops; hypertension; age > 40 years; and BMI > 30 kg/m2. OSA was highly prevalent in Norwegian adults with achondroplasia, which we believe is representative of this population worldwide. Follow-up of adults with achondroplasia should include assessment of symptoms and signs of OSA, with a low threshold for conducting an overnight sleep registration if findings suggestive of OSA are present.
7 citations
TL;DR: A Markov model is developed for DCIS progression, building on the established invasive breast cancer model, which shows most preclinical DCIS lesions progress or regress with a moderate sojourn time in the screening-detectable phase.
Abstract: ObjectivesIn addition to invasive breast cancer, mammography screening often detects preinvasive ductal carcinoma in situ (DCIS) lesions. The natural progression of DCIS is largely unknown, leading...
4 citations