Harish Babu

TL;DR: It is proposed that physical activity can “prime” the neurogenic region of the dentate gyrus for increased neurogenesis in the case the animal is exposed to an additional cognitive stimulus, here represented by the enrichment paradigm.

TL;DR: It is proposed that initial seizures induce ectopic precursor cell proliferation resulting in the dispersion of immature neurons within the adult granule cell layer, and seizure-generated neurons might contribute to the disease process of epilepsy.

TL;DR: It is argued that locomotion actually serves as an intrinsic feedback mechanism, signaling to the brain, including its neural precursor cells, increasing the likelihood of cognitive challenges, and boosting the potential for adult neurogenesis by physical activity increases the recruitment of cells following cognitive stimulation in an enriched environment.

TL;DR: Results indicate that melatonin through its receptor can modulate the survival of newborn neurons in the adult hippocampus, making it the first known exogenously applicable substance with such specificity.

TL;DR: The conditions required to generate adult murine dentate gyrus precursor cell cultures are reported and functional properties of precursor cells and their differentiated granule cell-like progeny in vitro are analyzed.