H
Harold E. Selick
Publications - 12
Citations - 3458
Harold E. Selick is an academic researcher. The author has contributed to research in topics: Antibody & Immunoglobulin light chain. The author has an hindex of 3, co-authored 12 publications receiving 3443 citations.
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Patent
Humanized immunoglobulins and methods of making the same
Cary L. Queen,Harold E. Selick +1 more
TL;DR: In this article, a method for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobalin and a framework region from an accepting human immunoglobin are provided.
Journal ArticleDOI
A humanized antibody that binds to the interleukin 2 receptor.
Cary L. Queen,William P. Schneider,Harold E. Selick,Philip W. Payne,Nicholas F. Landolfi,James F. Duncan,Nevenka M. Avdalovic,Michael Levitt,Richard P. Junghans,Thomas A. Waldmann +9 more
TL;DR: A "humanized" antibody is constructed by combining the complementarity-determining regions (CDRs) of the anti-Tac antibody with human framework and constant regions and has an affinity for p55 of 3 x 10(9) M-1, about 1/3 that of murine anti- Tac.
Patent
Polynucleotides encoding improved humanized immunoglobulins
TL;DR: In this paper, a method for producing, and compositions of, humanized immunoglobulins having one or more complementarity determining regions (CDR's) and possible additional amino acids from a donor immunoglobalin and a framework region from an accepting human immunoglobin are provided.
Patent
Immunoglobulines humanises, leurs production et utilization
Cary L. Queen,Harold E. Selick +1 more
TL;DR: In this paper, the authors propose a set of procedes to compare the sequence d'acides amines of a chain of immunoglobulines in an ensemble of chains with respect to a region of determination of complementarite.