Showing papers by "Harry A. Quigley published in 1983"
TL;DR: Compression of the successive lamina cribrosa sheets was the earliest detected abnormality, occurring in some eyes before the detection of visual field loss.
645 citations
TL;DR: The clinicopathologic features of Chandler's syndrome are elucidated based on a study of nine patients, and abnormalities of the endothelially-derived cells lining the posterior corneal surface, the inner surface of the trabecular meshwork, and the anterior iris surface are identified.
58 citations
TL;DR: The most important factor predisposing to dellen formation was poor tear-film integrity adjacent to the bleb, and the secretion of the aqueous tears seemed to have little or no effect on deLLen formation.
Abstract: Dellen may occur in the corneas of eyes with filtering blebs. Nine cases of such dellen were encountered in a series of 97 consecutive trabeculectomies. In two such patients, the dell progressed to a deep corneal ulcer, although in most cases it healed uneventfully with minor changes in therapy. The use of topical prednisolone acetate during the postoperative period may also contribute to dellen formation by inhibiting corneal epithelial wound healing. However, the most important factor predisposing to dellen formation was poor tear-film integrity adjacent to the bleb. The secretion of the aqueous tears seemed to have little or no effect on dellen formation. Almost all dellen occurred in eyes with large filtering blebs.
40 citations
TL;DR: Estimation of the number of surviving axons in the six optic nerves generally showed the greatest atrophy to be in the temporal sector in cross sections immediately behind the globe, which may result from particular vulnerability of macular axons to damage along the anterior visual pathway.
29 citations
TL;DR: Reexamined the data given in the Figure and came to different conclusions from those drawn by the authors, a result that would support the idea that the damage to cat optic nerve was vascular in cause.
Abstract: To the Editor. —In the JanuaryArchives(1983;101:94-97) Sossi and Anderson reported the results of an experiment on the mechanism of damage to cat optic nerve by intraocular pressure elevation of four hours, using the degree of axonal transport block as a measure of axonal injury. In some animals, BP was artificially lowered or raised to produce a wide range of tested IOP and mean BP. They sought to determine whether axonal injury is more closely correlated with absolute IOP (suggesting a mechanical effect) or more closely matches the perfusion pressure (mean BP—IOP), a result that would support the idea that the damage was vascular in cause. I admire both the care with which the experiment was performed and the large number of eyes studied; however, I reexamined the data given in the Figure and came to different conclusions from those drawn by the authors. First, I plotted
21 citations