A process for the production of 1-(3-(2-(1-benzothiophen-5- yl)ethoxy)propyl)azetidin-3-ol or salts thereof which comprises using as a starting compound a (phenylthio)acetic acid derivative represented by the general formula [1] or a salt thereof: [Chemical Formula 1] (wherein X1 is halogeno) is useful as a safe process for mass production of 1-(3-(2- (1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or salts thereof which are useful as remedies for central nervous system diseases and peripheral nerve diseases.

Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propyl)azetidin-3-ol or salts thereof

There is provided is a method for producing lactic acid from glycerol, which comprises culturing a specific bacterium capable of producing lactic acid in a culture medium containing glycerol, or making cells of the bacterium, processed cells of the bacterium or immobilized product thereof contact with glycerol.

Method for producing lactic acid

The invention discloses enterobacter cloacae and application thereof to preparation of L-2-amino-4 (hydroxyethylmethylphosphoryl)-butyric acid as an important chiral precursor of L-glufosinate The invention provides a strain capable of producing nitrilase, namely enterobacter cloacae ZJB-16007 The invention further provides a method for preparing the L-2-amino-4 (hydroxyethylmethylphosphoryl)-butyric acid as the important chiral precursor of the L-glufosinate by using a wet bacterium, obtained through fermentation culture of the enterobacter cloacae ZJB-16007, as a biocatalyst for catalyzing 2-amino-4 (hydroxyethylmethylphosphoryl)-butyronitrile The enterobacter cloacae has an important application prospect

Enterobacter cloacae and application thereof

Copper complex formazan compounds which have fiber-reactive properties and are very highly suitable for use as dyes for dyeing carboxamido-containing and/or hydroxy-containing material, such as fiber material, for example wool and cellulose fiber materials, have the general formula (1) ##STR1## where A is a benzene or naphthylene ring which may be substituted by substituents customary in dyes, such as halogen, nitro, alkyl and alkoxy, B is alkylene of 1 to 8 carbon atoms or alkenylene of 2 to 8 carbon atoms which may each be substituted by phenyl which in turn may contain the substituents customary in dyes, or is alkylene-phenylene or alkenylene-phenylene having lower alkylene and alkenylene radicals, while the phenylene radicals may in turn contain the substituents customary in dyes, or is a phenylene or naphthylene radical which may contain substituents customary in dyes, or is the bivalent radical of a heterocycle, such as furan, thiophene or benzimidazole, or --B--Z together is hydrogen, Z is a water-solubilizing group, such as sulfo, k is 1 or 2, m is 0, 1 or 2, n is 0, 1 or 2, the sum (m+n) is 1 to 4; X is oxygen or carbonyloxy, R is hydrogen or substituted or unsubstituted lower alkyl, D is substituted or unsubstituted phenylene or naphthylene, Y is vinyl or an ethyl group which contains in the β-position a substituent which is eliminatable under alkaline conditions, and M is hydrogen, an alkali metal or an alkaline earth metal.

Copper complex formazan compounds containing a cyanamido-S-triazinylamino radical and a fiber-reactive group of the vinylsulfone series, suitable as dyes

Elastic knitted cloth

PURPOSE:To industrially favorably obtain high purity carbon monoxide low in hydrogen content by decomposing formic acid by heating in the presence of a mineral acid using a zeolite based catalyst. CONSTITUTION:In the production method for carbon monoxide by decomposition by heating of the formic acid, the reaction is executed in the presence of a mineral acid using the zeolite-based catalyst. As the zeolite based catalyst, among catalysts, H-mordenite and H-ZMS-5 are suitable because they are excellent in acid resistance. When the formic acid of 40-100% purity is used, the reaction is executed efficiently. When the purity is less than 40%, the reaction unfavorably requires heating energy because the remainder except the formic acid is water. When the method is used, the high purity carbon monoxide which is usable in the semiconductor production area such as an integrated circuit and has >=99.9% purity is produced.

Production of high-purity carbon monoxide

PURPOSE:To obtain the subject compound useful as an intermediate for dyes, pigments, electronic chemicals, agricultural chemicals, drugs, etc., in a high yield by a simple process under a mild condition by reacting a halogenobenzene compound with a sulfide in a polar organic solvent as a reaction solvent. CONSTITUTION:A compound of formula I (X is Cl, Br; m is 2, 3) is reacted with a sulfide (preferably sodium hydrosulfide) in a polar organic solvent, preferably N-methyl-2-pyrrolidone, N,N-dimethylformaldehyde, sulfolane, ethylene glycol, etc., as a reaction solvent at 50-220 deg.C, preferably 120-170 deg.C, to obtain a halogenothiophenol of formula II (M is H, alkali metal). The reaction of the compound of formula II with a halogenated compound of formula III (Y is Cl, Br; R is 1-12C alkylene, phenylene) can easily give a sulfide compound of formula IV.

Production of halogenothiophenols and derivatives thereof

NEW MATERIAL:The compound of formula I (X is halogen; Y is halogen or atomic group of perhalogenic acid; R is 1-7C alkyl, aralkyl or aryl). EXAMPLE:3-Chloro-2-acetoxypropyl trimethyl ammonium chloride. USE:A synthetic intermediate for L-carnitine useful as a remedy for cardiopathy. PREPARATION:The compound of formula I can be produced by acylating 3- halogeno-2-hydroxypropyl trimethyl ammonium salt of formula II with an acid halide or acid anhydride in the presence or absence of solvent.

3-halogeno-2-acyloxypropyl trimethyl ammonium salt and production thereof

PURPOSE:To enable advantageous production of the title compound used as a thermally developing sensitive material, without the process for waste disposal by sulfonation, chlorination and reduction of a readily available and inexpensive diphenyl sulfide as a starting substance, followed by condensation reaction of the intermediate product with chloracetic acid and oxidation. CONSTITUTION:Diphenyl sulfide of formula I is used as a starting substance to effect sulfonation preferably with chlorosulfuric acid at -10-+50 deg.C to give 4-(phenylthio)benzenesulfonic acid of formula II. The product is chlorinated, preferably with thionyl chloride to give 4 (phenylthio)benzenesulfonyl chloride of formula III. The product is reduced, preferably with sodium sulfite to give the compound of formula IV, which is condensed with chloracetic acid, bromacetic acid or their ester, and the product of formula V (R is H, methyl, ethyl) is oxidized or oxidized, then hydrolyzed to give the compound of formula VI.

Production of (4-(phenylsulfonyl)phenylsulfonyl)acetic acid and related compound

PURPOSE:To prepare the title compound useful as an intermediate of medicine, pesticide, perfumery, etc., easily and economically, by treating p-aminobenzaldehyde and/or its polymer with a mineral acid in a specific solvent, diazotizing the product at low temperature, and hydrolyzing the diazotized compound. CONSTITUTION:The title compound is prepared by (1) reacting p-aminobenzaldehyde and/or its polymer obtained by the reaction of p-nitrotoluene with sodium polysulfide in an alkaline aqueous solution containing an alcohol, with a mineral acid such as sulfuric acid, etc. in a solvent composed of a water-soluble organic solvent such as alcohol, cyclic ether, lower fatty acid, etc. and water, (2) diazotizing the reaction product at a low temperature by conventional process, and (3) hydrolyzing the diazotized product. The weight ratio of the organic solvent to p-aminobenzaldehyde is pref. 1.5-5 to 1; the molar ratio of the mineral acid to the aldehyde is pref. 1.0-2.0 to 1; and the volume ratio of water to the organic solvent is pref. 0.1-50 to 1.

Hata Hiroyuki

Papers

Production of high-purity carbon monoxide

Production of halogenothiophenols and derivatives thereof

3-halogeno-2-acyloxypropyl trimethyl ammonium salt and production thereof

Production of (4-(phenylsulfonyl)phenylsulfonyl)acetic acid and related compound

Preparation of paraahydroxybenzaldehyde