Turner syndrome affects 25-50 per 100,000 females and can involve multiple organs through all stages of life, necessitating multidisciplinary approach to care. Previous guidelines have highlighted this, but numerous important advances have been noted recently. These advances cover all specialty fields involved in the care of girls and women with TS. This paper is based on an international effort that started with exploratory meetings in 2014 in both Europe and the USA, and culminated with a Consensus Meeting held in Cincinnati, Ohio, USA in July 2016. Prior to this meeting, five groups each addressed important areas in TS care: 1) diagnostic and genetic issues, 2) growth and development during childhood and adolescence, 3) congenital and acquired cardiovascular disease, 4) transition and adult care, and 5) other comorbidities and neurocognitive issues. These groups produced proposals for the present guidelines. Additionally, four pertinent questions were submitted for formal GRADE (Grading of Recommendations, Assessment, Development and Evaluation) evaluation with a separate systematic review of the literature. These four questions related to the efficacy and most optimal treatment of short stature, infertility, hypertension, and hormonal replacement therapy. The guidelines project was initiated by the European Society for Endocrinology and the Pediatric Endocrine Society, in collaboration with The European Society for Pediatric Endocrinology, The Endocrine Society, European Society of Human Reproduction and Embryology, The American Heart Association, The Society for Endocrinology, and the European Society of Cardiology. The guideline has been formally endorsed by the European Society for Endocrinology, the Pediatric Endocrine Society, the European Society for Pediatric Endocrinology, the European Society of Human Reproduction and Embryology and the Endocrine Society. Advocacy groups appointed representatives who participated in pre-meeting discussions and in the consensus meeting.

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Clinical practice guidelines for the care of girls and women with Turner syndrome: proceedings from the 2016 Cincinnati International Turner Syndrome Meeting

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Oral Health Surveys: Basic Methods

https://courses.washington.edu/gradorth/Ortho%20565%20Spring%20Theory/Suir%20AJODO_2004.pdf

Delayed tooth eruption: pathogenesis, diagnosis, and treatment. A literature review.

Objectives Cone beam computed tomography (CBCT) images of ideally positioned and systematically mispositioned dry skulls were measured using two-dimensional and three-dimensional software measurement techniques. Image measurements were compared with caliper measurements of the skulls. Study design Cone beam computed tomography volumes of 28 skulls in ideal, shifted, and rotated positions were assessed by measuring distances between anatomic points and reference wires by using panoramic reconstructions (two-dimensional) and direct measurements from axial slices (three-dimensional). Differences between caliper measurements on skulls and software measurements in images were assessed with paired t tests and analysis of variance (ANOVA). Results Accuracy of measurement was not significantly affected by alterations in skull position or measurement of right or left sides. For easily visualized orthodontic wires, measurement accuracy was expressed by average errors less than 1.2% for two-dimensional measurement techniques and less than 0.6% for three-dimensional measurement techniques. Anatomic measurements were significantly more variable regardless of measurement technique. Conclusions Both two-dimensional and three-dimensional techniques provide acceptably accurate measurement of mandibular anatomy. Cone beam computed tomography measurement was not significantly influenced by variation in skull orientation during image acquisition.

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Accuracy of measurements of mandibular anatomy in cone beam computed tomography images

The existence of an interaction among bite force magnitude, jaw muscle size (e.g., cross-sectional area, thickness), and craniofacial morphology is widely accepted. Bite force magnitude depends on the size of the jaw muscles and the lever arm lengths of bite force and muscle forces, which in turn are dictated by craniofacial morphology. In this study, the relative contributions of craniofacial morphology and jaw muscle thickness to the bite force magnitude were studied. In 121 adult individuals, both magnitude and direction of the maximal voluntary bite force were registered. Craniofacial dimensions were measured by anthropometrics and from lateral radiographs. The thicknesses of the masseter, temporal, and digastric muscles were registered by ultrasonography. After a factor analysis was applied to the anthropometric and cephalometric dimensions, the correlation between bite force magnitude, on the one hand, and the "craniofacial factors" and jaw muscle thicknesses, on the other, was assessed by stepwise multiple regression. Fifty-eight percent of the bite force variance could be explained. From the jaw muscles, only the thickness of the masseter muscle correlated significantly with bite force magnitude. Bite force magnitude also correlated significantly positively with vertical and transverse facial dimensions and the inclination of the midface, and significantly negatively with mandibular inclination and occlusal plane inclination. The contribution of the masseter muscle to the variation in bite force magnitude was higher than that of the craniofacial factors.

Contribution of Jaw Muscle Size and Craniofacial Morphology to Human Bite Force Magnitude

The aims of this investigation were to study the relation between facial morphology and bite force at different ages during growth and to investigate possible relations between bite force and the variables age, finger force, stature, and sex in growing healthy individuals. One hundred and thirty-six individuals were included, consisting of six groups of males and females, 7-9, 10-12, and 20-24 years old. Standardized photographs were taken to determine the facial type. The occlusal relationship, body height, finger force, maximal bite force, and bite force endurance amplitude were recorded. All bite force variables and finger force increased with age in both sexes. A positive correlation was found between the maximal bite force in the incisor region and the ratio of upper to lower facial height; this is, subjects with a high bite force had a relatively short lower anterior height. The maximal bite force for molars and endurance amplitude were positively correlated to stature and finger force but not to facial characteristics. A longitudinal study to follow each individual child during growth would be of interest to evaluate the importance of muscular influence on facial growth.

The relationship between maximal bite force, bite force endurance, and facial morphology during growth: A cross-sectional study

The aim of this study was to develop and apply a reliable method of measuring the effects of condylar lesions quantitatively on panoramic radiographs. Three different types of machines were tested. Two dry skulls were exposed in six positions in each machine, and the relative size of the condyle in relation to ramus height was calculated. The results showed good validity for the reference points used. The head position did not contribute to the variation in the measurements, but the type of panoramic machine had some influence. It was concluded that the method may be applied when calculating condylar ratios, provided that the same panoramic machine is used. The relative height of the condyle in relation to ramus height was measured bilaterally in three groups of children, with either normal or postnormal occlusion or with juvenile chronic arthritis (JCA), to detect possible asymmetries and define differences in the relative condylar height. The JCA group had a significantly shorter relative condylar height, and asymmetries were commoner than in the other two groups.

Condylar height on panoramic radiographs: A methodologic study with a clinical application

Craniofacial structure in children with juvenile chronic arthritis (JCA) compared with healthy children with ideal or postnormal occlusion

The aim of this project was to study the craniofacial morphology, dental occlusion, dental maturation and tooth eruption in short-statured boys with growth hormone secretion ranging from low to high. The measurements from lateral and posteroanterior cephalograms, orthopantomograms and plaster models were used. Almost all linear measurements of the facial structures were significantly smaller. A disproportionate growth in the cranial base structures as well as in the jaws resulted in facial retrognathia, a proportionately smaller posterior than anterior facial height, and a steep vertical inclination of the mandible. Dental crowding was more common and the overbite was small. Dental maturity and tooth eruption were delayed 1.2 and 1.3 yr, respectively. No significant differences between the idiopathic short-statured and the growth hormone-deficient group in any of the above-mentioned variables were found. It can be concluded that although most of the cephalometric variables measured differed significantly from the average, the facial appearance of the boys is not conspicuous and is of minor clinical importance. However, the short-statured boys might be in greater need of orthodontic treatment due to the higher percentage of dental crowding.

Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency.

The craniofacial growth in children with juvenile chronic arthritis (JCA), especially that of the mandible, and the degree of destruction of the mandibular condyles vary depending on the heterogeneity in duration and intensity of the disease. In JCA children showing destruction of the temporomandibular joint, the dentofacial morphology is characterized by overall smaller dimensions of the mandible, mandibular retrognathia, a steep mandibular plane, Class II malocclusion, dental crowding, and frontal open bite. In children with unilateral condylar destruction, asymmetries will develop, with the chin deviating to the affected side. The facial morphology of JCA children with condylar lesions becomes more abnormal during growth, reflecting a decelerated mandibular development and a backward-rotating growth pattern. The main single cause of the deviating craniofacial growth is mandibular condylar destruction. Other factors that may influence the craniofacial growth are head posture, soft tissue stretching, disease activity and drug therapy, type of onset of the disease, muscle weakness, decreased functional ability, and orthodontic treatment.

Heidrun Kjellberg

Papers

The relationship between maximal bite force, bite force endurance, and facial morphology during growth: A cross-sectional study

Condylar height on panoramic radiographs: A methodologic study with a clinical application

Craniofacial structure in children with juvenile chronic arthritis (JCA) compared with healthy children with ideal or postnormal occlusion

Craniofacial morphology, dental occlusion, tooth eruption, and dental maturity in boys of short stature with or without growth hormone deficiency.

Craniofacial growth in juvenile chronic arthritis.