The invention relates to stable oleaginous cosmetic or therapeutic foam compositions containing certain active agents, having unique therapeutic properties and methods of treatment using such compositions. The foamable composition includes at least one solvent selected from a hydrophobic solvent, a silicone oil, an emollient, a co-solvent, and mixtures thereof, wherein the solvent is present at a concentration of about 70% to about 96.5% by weight of the total composition, at least a non-ionic surface-active agent at a concentration of about 0.1% to less than about 10% by weight of the total composition; at least one gelling agent at a concentration of about 0.1% to about 5% by weight of the total composition; a therapeutically effective amount of at least one active agent; and at least one liquefied or compressed gas propellant, at a concentration of about 3% to about 25% by weight of the total composition.

Oleaginous pharmaceutical and cosmetic foam

The present invention relates to compositions and methods of sanitizing and moisturizing skin surfaces.

Skin sanitizing compositions

A hygroscopic pharmaceutical composition includes at least one hygroscopic substance at a concentration sufficient to provide an Aw value of at least 0.9 and an antiinfective agent. A foamble pharmaceutical carrier includes about 50% to about 98% of a polar solvent selected from the group consisting of a polyol and PEG; 0% to about 48% of a secondary polar solvent; about 0.2% to about 5% by weight of a surface-active agent; about 0.01% to about 5% by weight of at least one polymeric agent; and a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Foamable vehicle and pharmaceutical compositions thereof

The present invention relates to polymeric medical articles comprising combinations of triclosan and silver-containing compounds. It is based, at least in part, on the discovery that these agents act synergistically, thereby permitting the use of relatively low levels of both agents. While it had been previously found that triclosan can be particularly useful when used in conjunction with chlorhexidine, it has been further discovered that medical articles having suitable antimicrobial properties may be prepared, according to the present invention, which contain triclosan without chlorhexidine. Such medical articles offer the advantage of preventing or inhibiting infection while avoiding undesirable adverse reactions to chlorhexidine by individuals that may have sensitivity to chlorhexidine.

Triclosan and silver compound containing medical devices

The invention relates to an alcohol-free cosmetic or pharmaceutical foam composition comprising water, a hydrophobic solvent, a surface-active agent, a gelling agent, an active component selected from the group of urea, hydroxy acid and a therapeutic enhancer and a propellant. The foam further comprises active agents and excipients with therapeutic properties having enhanced skin penetration.

Penetrating pharmaceutical foam

The use is claimed of glycerinmonoalkyl ethers as skin-care additives, partic. for cosmetic cleaning and care compsns. Pref. the ethers are of formula (I), where R = 3-14C alkyl. Pref. R = 5-12C opt. branched alkyl, esp. 1-heptyl, 1-(2- ethylhexyl), 1-octyl, 1-decyl or 1-dodecyl. The cosmetic prod. contains 0.01-10 (most pref. 0.5-3) wt.% (I). USE/ADVANTAGE - The prod. prevents drying of the skin, regulates the moisture content, provides sufficient fat and imparts a pleasant touch to the skin. (I) is used as an aq. and/or alcoholic soln. or as an emulsion with a mixt. of surfactant such as emulsifiers and/or other additives. Cosmetic prods. include solid or liquid soaps, showerbath, shower gel, foam bath, shampoo, wash lotion, cream, after-shave etc.

Glycerin monoalkyl ether used as skincare additives in cosmetic compsn. - prevents drying of skin, regulates moisture content and gives pleasant feel

Deodorant compositions comprise glycerin monoalkyl ethers of the formula ##STR1## in which R is a branched or unbranched C 6 -C 18 alkyl in combination with other deodorant ingredients. Preferably R is C 8 to C 12 alkyl; more particularly, C 8 alkyl; and most preferably, 2-ethylhexyl.

Deodorizing active ingredients

The invention is directed to a composition comprising an alkyl alcohol component, at least one glycerol monoalkyl ether and water.

Skin antiseptic and hand disinfectant

A preservative, for compositions having an aqueous phase, comprising a) 5 to 60% by weight of an organic acid selected from the group consisting of benzoic acid, 4-hydroxybenzoic acid, salicylic acid, formic acid, acetic acid, propionic acid, sorbic acid, undecylenic acid and dehydracetic acid or their mixtures including their sodium, potassium, calcium, magnesium, ammonium and ethanolamine salts b) 10 to 95% by weight of alcohols of the general formulae I, II or III ##STR1## in which R 1 denotes hydrogen, an n-alkyl, iso-alkyl or alkoxy radical having 1 to 3 C atoms, and R 2 and R 3 denote hydrogen or a CH 3 -- or C 2 H 5 -- radical and n has the value of 3 or 4, and c) 0.1 to 20% by weight of one or more poly(hexa-methylenebiguanide) salts of the general formula ##STR2## in which Z represents hydrochloride, acetate, lactate, benzoate, propionate, 4-hydroxybenzoate, sorbate or salicylate; and n has the value of 4 to 6, in combination in a customary carrier or solvent.

Preservatives and their use

A preservative for prods. or systems with an aq. phase contains in a conventional carrier or solvent, a three component mixt. consisting of (amts. based on the active ingredient) (a) 5-60 wt.% of an organic acid chosen from benzoic acid, 4-hydroxybenzoic aicd, salicyclic acid, methanoic acid, ethanoic acid, propionic acid, sorbic acid, undecenoic acid and/or dehydracetic acid or their Na, K, Ca, Mg, NH4 or ethanolamine salts; (b) 10-95 wt.% of an alcohol of formula (I), (II) or (III); and (c) 0.1-20 wt.% of one or more poly(hexamethylene biguanide) salts of formula (IX). R1=H, n-alkyl, iso-alkyl or alkoxy each contg. 1-3C; R2 and R3=each H, Me or Et; n=3-4; m=4-6. x=hydrochloride, ethanoate, lactate, benzoate, propionate, 4-hydroxybenzoate, sorbate or salicylate. USE/ADVANTAGE - The preservative can be used in shampoos, cremes, lotions i.e. for cosmetic prods. with rinse-off and leave-on applications and for prods. used in washing and cleaning such as rinses and fabric softeners and in formulations for topical use of pharmaceuticals. The components act synergistically and have a broad spectrum of antimicrobial activity, even at low concns. The use of formaldehyde and other preservatives such as isothiazolinones which are environmentally polluting and toxic to humans is avoided.

Preservative for use in cosmetics, pharmaceuticals and cleaning prods. - contains organic acid, benzyl or phenoxy-alkyl alcohol and poly-hexa:methylene bi:guanide salt

Heinz Dr Eggensperger

Papers

Glycerin monoalkyl ether used as skincare additives in cosmetic compsn. - prevents drying of skin, regulates moisture content and gives pleasant feel

Deodorizing active ingredients

Skin antiseptic and hand disinfectant

Preservatives and their use

Preservative for use in cosmetics, pharmaceuticals and cleaning prods. - contains organic acid, benzyl or phenoxy-alkyl alcohol and poly-hexa:methylene bi:guanide salt