H
Helle Malerod
Researcher at University of Oslo
Publications - 15
Citations - 625
Helle Malerod is an academic researcher from University of Oslo. The author has contributed to research in topics: Hydrophilic interaction chromatography & High-performance liquid chromatography. The author has an hindex of 13, co-authored 15 publications receiving 575 citations. Previous affiliations of Helle Malerod include Oslo University Hospital.
Papers
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Journal ArticleDOI
On-line solid phase extraction–liquid chromatography, with emphasis on modern bioanalysis and miniaturized systems
Magnus Rogeberg,Helle Malerod,Helle Malerod,Hanne Roberg-Larsen,Cecilie Aass,Steven Ray Wilson +5 more
TL;DR: On-line solid phase extraction (SPE)-liquid chromatography (LC) allows for automated, sensitive, precise and selective bioanalysis, and certain columns, configurations and hardware can improve robustness.
Book ChapterDOI
A Critical Review of Trypsin Digestion for LC-MS Based Proteomics
Hanne Kolsrud Hustoft,Helle Malerod,Steven Ray Wilson,Léon Reubsaet,Elsa Lundanes,Tyge Greibrokk +5 more
TL;DR: The failure in the search for biomarkers as indicators of disease, the difficulties of protein arrays, the uncertainty of quantification in “shotgun proteomics”, database shortcomings, and finally the huge disappointment in the area of drug discovery are addressed.
Journal ArticleDOI
Recent advances in on-line multidimensional liquid chromatography
TL;DR: Different aspects related to the compatibility of separation principles and column dimensions are highlighted and recent applications using on-line mainly two-dimensional (2D) LC have been included.
Journal ArticleDOI
Critical assessment of accelerating trypsination methods.
TL;DR: Recommendations regarding optimizing and evaluating the tryptic digestion for both targeted and comprehensive proteomics are given, and a digestion method suitable as the first method for newcomers in Comprehensive proteomics is suggested.
Journal ArticleDOI
Hydrophilic interaction chromatography of nucleoside triphosphates with temperature as a separation parameter
Elin Johnsen,Steven Ray Wilson,Ingvild Odsbu,Andreas Krapp,Helle Malerod,Kirsten Skarstad,Elsa Lundanes +6 more
TL;DR: The polymer-based ZIC-pHILIC column gave significantly better separations and peak shape than a silica-based X-ray diffraction column, and could be used to fine tune separation.