Hellen Karine Stulzer

TL;DR: In this paper, an ionic gelation technique was applied to form nanoparticles through linkages between tripolyphosphate (TPP) and chitosan (CTS) and the formulation was optimized using a 2 3 factorial design to analyze the effect of the pH, CTS:TPP ratio and acetic acid concentration in size and charge of the particles.

TL;DR: In this paper, the authors obtained microparticles containing acyclovir (ACV) and chitosan cross-linked with tripolyphosphate using the spray-drying technique, which was evaluated through loading efficiency, differential scanning calorimetry (DSC), thermogravimetric analysis (TG), X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), in vitro release and stability studies.

TL;DR: The results obtained showed that the alginate/chitosan microparticles represent an efficient system for the controlled-release of RIF, and the dissolution efficiencies were similar for both formulations.

TL;DR: In this article, a possible drug-excipient interaction was observed with magnesium stearate by differential scanning calorimetry (DSC) and thermogravimetric (TG) analysis completed by X-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR) were used for compatibility studies.

TL;DR: The hypochlorous-acid-scavenging activity and 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation discoloration assay confirmed that the antioxidant activity of PHBV/PCL microparticles was kept, but was dependent on the microparticle morphology and dissolution profile.