Showing papers by "Hemangi Sane published in 2017"
23 Feb 2017
TL;DR: This work is licensed to www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/ 3.0/).
Abstract: php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). Journal of Neurorestoratology 2017:5 51–57 Journal of Neurorestoratology Dovepress
6 citations
14 Jun 2017
TL;DR: This chapter focuses on recent advances in the application of stem cells as a therapeutic tool for some of the common neurode‐ velopmental disorders (cerebral palsy, autism, intellectual disability and muscular dys‐ trophy).
Abstract: Pediatric neurological disorders represent a major part of the disabilities worldwide. In over 10 decades of research to find a cure for these disorders, medical science has not been able to repair the underlying brain injury. This chapter focuses on recent advances in the application of stem cells as a therapeutic tool for some of the common neurode‐ velopmental disorders (cerebral palsy, autism, intellectual disability and muscular dys‐ trophy). The mechanism of action of stem cells in each disorder has been explained. A review of clinical data has been described giving a clear understanding of current status of stem cell therapy in these disorders. Various factors influencing the outcome of stem cell therapy such as different types of cells, different routes of administration and dosage and frequency of transplantation have also been discussed. Our experience of treating these disorders is exhibited in the form of our published data. Use of novel monitoring tools such as MRI MSK and PET‐CT scan brain to track the changes occurring at cellular level after stem cell therapy are described. We also highlight the importance of a multi‐ disciplinary approach of combining rehabilitation with stem cell therapy.
3 citations
TL;DR: Increased metabolic activity in various areas of the brain was observed and changes also correlated to the functional improvements observed in the patient, suggesting stem cell transplantation may have a promising future as a therapeutic intervention in chronic TBI.
3 citations
TL;DR: It is hypothesized that cellular therapy holds great potential as a treatment modality for autism in combination with standard rehabilitation therapy and PET CT scan of the brain showed a balancing effect in the metabolism of affected areas.
Abstract: Autism is a complex neurodevelopmental disorder defined by a triad of deficits including impaired social interaction communication and behaviour With greater understanding of mechanism of action of cellular therapy it is now possible to address the pathology of autism Here is a case of a six and a half year old boy with autism who was administered autologous bone marrow mononuclear cells BMMNCs intrathecally followed by an intensive rehabilitation program On follow up at months and months post intervention he showed significant symptomatic improvements with no major side effects At the end of months ISAA score improved from to The Wee FIM showed improvement to CARS score reduced from mild to moderate autism to mild autism PET CT scan of the brain performed pre intervention and seven months post showed a balancing effect in the metabolism of affected areas It also showed reduction in hypermetabolism of the frontal parietal and temporal lobe bilaterally and increase in metabolism of the previously hypometabolic bilateral cerebelli The changes observed on the PET CT scan of the brain correlated with clinical improvements We hypothesize that cellular therapy holds great potential as a treatment modality for autism in combination with standard rehabilitation therapy Randomized controlled trials are warranted to study their long term effects in treating autism
2 citations
29 May 2017
TL;DR: Improvements were noticed in oromotor functions, neck control and sitting balance, awareness, understanding of surrounding, and improved brain metabolism in basal ganglia, cerebellum, hippocampus and thalamus as observed in Positron Emission Tomography-Computed Tomography Scan.
Abstract: Cerebral palsy (CP) is characterized by a non-progressive motor impairment related to brain injury early in development. It may be associated with other deficits such as intellectual disability, speech and language and oromotor problems. In many cases, the cause of CP may not be apparent. So, the current treatment options are mostly focused on the symptomatic management. Herein, we present a case of an eight year old child diagnosed as cerebral palsy with intellectual disability. He was administered with autologous bone marrow derived mononuclear cells intrathecally. Eight months after intervention, Gross Motor Function Measure (GMFM) scale score changed from 1.9 to 3.077 depicting improvement in movement. On follow up improvements were noticed in oromotor functions, neck control and sitting balance, awareness, understanding of surrounding. These functional improvements correlated with the improved brain metabolism in basal ganglia, cerebellum, hippocampus and thalamus as observed in Positron Emission Tomography-Computed Tomography (PET-CT) Scan. No major side effects were recorded after intervention. The results suggest that autologous bone marrow derived mononuclear cells have a significant potential as a therapeutic strategy for CP.