Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.

Fused Heterocyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Chemistry of pyramidalized alkenes

The Diels–Alder reaction of β-sulfonylnitroethylene with cyclopentadiene, cyclohexadiene or substituted anthracenes followed by treatment with ethyl isocyanoacetate in the presence of DBU gives pyrroles fused with bicyclo[2.2.1]heptadiene and bicyclo[2.2.2]octadiene skeletons, or triptycene-types of pyrrole, respectively, which are precursors for novel porphyrins fused with polycyclic skeletons.

A new synthesis of pyrroles fused with polycyclic skeletons

Fused cyclic succinimide compounds and analogs thereof, modulators of nuclear hormone receptor function

Fused heterocyclic compounds and analogs thereof, modulators of nuclear hormone receptor function

2-Phenyl- and 2-(p-tolyl)-4,7-dihydro-4,7-methano-2H-isoindole were synthesized by treatment of 3-(diethoxymethyl)bicyclo[2.2.1]hepta-2,5-diene-2-carbaldehyde with aniline or p-toluidine, followed by reduction with sodium borohydride and acid-catalyzed cyclization. It was concluded that the previous claim of the synthesis of methanoisoindole derivatives was incorrect. 4,7-Dihydro-4,7-methanoisobenzofuran was prepared by the reduction of the norbornadiene-monocarbaldehyde with sodium borohydride and subsequent treatment with Amberlyst-15. The p-tolylmethanoisoindole reacted with dimethyl acetylenedicarboxylate to give a novel 1 : 3 adduct. On the other hand, in the reaction of the methanoisobenzofuran with N-phenylmaleimide, spontaneous oxidation of the Diels–Alder cycloadduct took place to give exclusively its epoxide.

Norbornadiene-Fused Heterocycles: Syntheses and Cycloaddition Reactions of 2-Aryl-4,7-dihydro-4,7-methano-2H-isoindoles and 4,7-Dihydro-4,7-methanoisobenzofuran

Norbornadiene‐Fused Heterocycles: Syntheses and Cycloaddition Reactions of 2‐Aryl‐4,7‐dihydro‐4,7‐methano‐2H‐isoindoles and 4,7‐ Dihydro‐4,7‐methanoisobenzofuran.

Hiroki Takase

Papers

Norbornadiene-Fused Heterocycles: Syntheses and Cycloaddition Reactions of 2-Aryl-4,7-dihydro-4,7-methano-2H-isoindoles and 4,7-Dihydro-4,7-methanoisobenzofuran

Norbornadiene‐Fused Heterocycles: Syntheses and Cycloaddition Reactions of 2‐Aryl‐4,7‐dihydro‐4,7‐methano‐2H‐isoindoles and 4,7‐ Dihydro‐4,7‐methanoisobenzofuran.