Hiroko Kondo

TL;DR: An artificial intelligence (AI) system that automatically detects early signs of colorectal cancer during colonoscopy and can alert endoscopists in real-time to avoid missing abnormalities such as non-polypoid polyps during Colonoscopy, improving the early detection of this disease.

TL;DR: The crystal structures of the reduced and oxidized forms of the AnkG s-palmitoylation domain are solved and multiple long-term coarse-grained molecular dynamics simulations are used to analyze their membrane association and suggest that AnkG in the juxtamembrane region is primed to accept lipid modification at Cys and constitutes a rigid structural base upon which a membrane-excitation platform can be assembled.

TL;DR: The voltage-gated proton channel (Hv1/VSOP) is inhibited by Zn2+, of which the binding site is located in the extracellular region and the most probable coordination structure was proposed as a tetrahedral geometry with ligands of carboxylate and imidazole groups in addition to a water molecule

TL;DR: In this article, the effects of heme distortions on the chemical properties in two protein classes, oxidoreductases and oxygen carrier proteins, were studied by a combination of statistics and quantum chemistry.

TL;DR: An enhanced exchange algorithm for REM not meeting the detailed balance condition (DBC), but satisfying the balance condition in all considered exchanges between two replicas is proposed and is expected to reduce the required number of replicas.