Showing papers by "Hiroshi Hatanaka published in 1985"
Patent•
30 Nov 1985
TL;DR: In this article, tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation and autoimmune diseases, infectious diseases, and the like can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
Abstract: This invention relates to tricyclo compounds useful for treatment and prevention of resistance by transplantation, graft-versus-host diseases by medulla ossium transplantation, autoimmune diseases, infectious diseases, and the like, which can be represented by the following formula: to a process for their production, to a pharmaceutical composition containing the same and to a use thereof.
270 citations
Patent•
03 Dec 1985
TL;DR: In this paper, a microbial strain belonging to the Streptomyces genus and capable of producing FR-900506 substance, FR- 900520 substance and/or FR900525 substance is calcutured in a medium and the compound of formula is separated from the cultured product.
Abstract: NEW MATERIAL:The compound of formula (R is OH or protected OH; R is H,. OH ore protected OH; methyl, ethyl propyl or allyl; n is 1 or 2; the bond containing the dotted line is single or double) or its salt. E X A M P L E : 1 7 - A l l y l - 1, 1 4 - d i h y d r o x y - 1 2 - [ 2 - ( 4 - h y d r o x y - 3 USE:Immunosuppressor and antibiotic agent. PREPARATION:A microbial strain belonging to Streptomyces genus and capable of producing FR-900506 substance, FR-900520 substance and/or FR900525 substance, e.g. Streptomyces tsukubaensis No.9993 (FERM BP-927) is calcutured in a medium and the compound of formula is separated from the cultured product.
19 citations