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Showing papers by "Hiroshi Inoue published in 2011"

Journal Article•DOI•
Novel ribbon-type nuclear factor of activated T cells decoy oligodeoxynucleotides preclude airways hyperreactivity and Th2 cytokine expression in experimental asthma.

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Yutaka Nakamura1, Hiromi Nagashima, Masachika Akiyama, Atsuko Sato, Takayuki Miyamoto, Nobuhito Sasaki, Hiroo Nitanai, Koko Kowata, Toshihide Nakadate, Hitoshi Kobayashi, Noriyuki Uesugi, Tamotsu Sugai, Terutaka Kakiuchi, Hiroshi Inoue, Kohei Yamauchi •
Iwate Medical University1
01 Jan 2011-International Archives of Allergy and Immunology
TL;DR: The inhibitory effect of ribbon-type decoy ODNs against NFAT on the induction of bronchial asthma is suggested and adoptively transferred CD3+ T cells, which are transfected with NFAT decoy, may be an effective strategy for the treatment of asthma.
Abstract: Background: Nuclear factor of activated T cells (NFAT) is required for the differentiation of Th2 responses, so we examined its role in mouse experimental asthma and tested the hypo

5 citations