H
Hiroshi Kosaka
Researcher at Kindai University
Publications - 10
Citations - 399
Hiroshi Kosaka is an academic researcher from Kindai University. The author has contributed to research in topics: Ames test & Furylfuramide. The author has an hindex of 7, co-authored 10 publications receiving 377 citations.
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Antimutagenic activity of flavonoids from Pogostemon cablin.
TL;DR: A methanol extract from Pogostemon cablin showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-Furyl)acrylamide (furylfuramide).
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Antimutagenic activity of isoflavone from Pueraria lobata.
TL;DR: A methanol extract from Pueraria lobata showed a suppressive effect on umu gene expression of the SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-2-Furyl)acrylamide (furylfuramide) and its methylated derivative showed suppression of SOS-inducing activity.
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Antimutagenic activity of isoflavones from soybean seeds (Glycine max merrill).
TL;DR: Two isoflavones, daidzein and genistein, showed a suppressive effect on umu gene expression of the SOS response in Salmonellatyphimurium TA1535/pSK1002 against the mutagen 3-amino-1, 4-dimethyl-5H-pyrido[4,3b]indole (Trp-P-1), which requires liver metabolizing enzymes.
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Moscatilin from Dendrobium nobile, a Naturally Occurring Bibenzyl Compound with Potential Antimutagenic Activity
Mitsuo Miyazawa,Hideo Shimamura,Sei-ichi Nakamura,Wataru Sugiura,Hiroshi Kosaka,Hiromu Kameoka +5 more
TL;DR: In this article, a bibenzyl compound that possesses antimutagenic activity was isolated from the storage stem of Dendrobium nobile and used to suppress the expression of the umu gene following the induction of SOS response in Salmonella typhimurium TA1535/pSK1002.
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Antimutagenic activity of polymethoxyflavonoids from Citrus aurantium.
TL;DR: The methanol extract from Citrus aurantium showed a suppressive effect on umu gene expression of SOS response in Salmonella typhimurium TA1535/pSK1002 against the mutagen 2-(2-furyl)-3-(5-nitro-1,4-dimethyl-5H-pyrido[4,3-b]indole)acrylamide (furylfuramide).