Showing papers by "Hiroshi Yoshida published in 2020"

Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system.

Abstract: Accumulating evidence demonstrates that not only sustained elevation of blood glucose levels but also the glucose fluctuation represents key determinants for diabetic complications and mortality Current closed-loop insulin therapy option is limited to the use of electronics-based systems, although it poses some technical issues with high cost Here we demonstrate an electronics-free, synthetic boronate gel-based insulin-diffusion-control device technology that can cope with glucose fluctuations and potentially address the electronics-derived issues The gel was combined with hemodialysis hollow fibers and scaled suitable for rats, serving as a subcutaneously implantable, insulin-diffusion-active site in a manner dependent on the subcutaneous glucose Continuous glucose monitoring tests revealed that our device not only normalizes average glucose level of rats, but also markedly ameliorates the fluctuations over timescale of a day without inducing hypoglycemia With inherent stability, diffusion-dependent scalability, and week-long & acute glucose-responsiveness, our technology may offer a low-cost alternative to current electronics-based approaches Here, the authors develop an in vivo insulin delivery system which consists of a glucose responsive gel combined with hemodialysis hollow fibers This system is electronics-free, temperature independent, and can stably sustain acute glucose-responsiveness in rats

Sub-GHz Phase-Based Ranging System: Implementation and Evaluation

Abstract: A prototype phase-detection ranging system based on the automotive remote /tele-control narrowband ARIB STDT108 standard and operating in the sub-GHz band is designed, built, and evaluated. The prototype uses a pair of transceivers operating asynchronously. Problems with the frequency offset and initial phase are overcome by using an exchange sequence. The prototype employing 5. 6MHz bandwidth achieves a distance error of 0.09 m under ideal environments without multipath and 0.88 m in outdoor conditions within the range of $6.0\,\,\mathrm {m}\times 6.0\mathrm {m}$ area.