Techniques are provided for searching on three dimensional (3D) objects across large, distributed repositories of 3D models. 3D shapes are created for input to a search system; optionally user-defined similarity criterion is used, and search results are interactively navigated and feedback received for modifying the accuracy of the search results. Search input can also be given by picking 3D models from a cluster map or by providing the orthographic views for the 3D model. Feedback can be given by a searcher as to which models are similar and which are not. Various techniques adjust the search results according to the feedback given by the searcher and present the new search results to the searcher.

Methods, systems, and data structures for performing searches on three dimensional objects

Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus. Isolated peptides of the Bacillus anthracis anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

Replikin peptides and uses thereof

Peptides of influenza virus hemagglutinin protein and Plasmodium falciparum malaria antigen, antibodies specific for the peptides, influenza vaccines, malaria vaccines and methods of stimulating the immune response of a subject to produce antibodies to influenza virus or malaria are disclosed. Also disclosed are methods for formulating vaccines for influenza virus.

Replikin peptides in rapid replication of glioma cells and in influenza epidemics

Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01-107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.

Anthrax and small pox replikins and methods of use

The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.

Replikin peptides and antibodies therefore

A method of searching a database of three-dimensional protein structures. The method comprises the steps of setting a three-dimensional protein structure; forming a two-dimensional binary distance map based on the three-dimensional protein structure; forming a one-dimensional peripheral distribution based on the distance map; and comparing the one-dimensional peripheral distribution of a protein structure with that of another protein structure a dynamic programming algorithm. The method increases detection sensitivity and search speed.

Hiroyuki Toh

Papers

Method of searching database of three-dimensional protein structures