H
Hisayoshi Takamoto
Researcher at Hamamatsu Photonics
Publications - 10
Citations - 185
Hisayoshi Takamoto is an academic researcher from Hamamatsu Photonics. The author has contributed to research in topics: Microscopy & Spatial light modulator. The author has an hindex of 5, co-authored 10 publications receiving 158 citations.
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Journal ArticleDOI
Two Distinct Amyloid β-Protein (Aβ) Assembly Pathways Leading to Oligomers and Fibrils Identified by Combined Fluorescence Correlation Spectroscopy, Morphology, and Toxicity Analyses
Satoko Matsumura,Keiko Shinoda,Mayumi Yamada,Satoshi Yokojima,Masafumi Inoue,Takayuki Ohnishi,Tetsuya Shimada,Kazuya Kikuchi,Dai Masui,Shigeki Hashimoto,Michio Sato,Akane Ito,Manami Akioka,Shinsuke Takagi,Yoshihiro Nakamura,Kiyokazu Nemoto,Yutaka Hasegawa,Hisayoshi Takamoto,Haruo Inoue,Shinichiro Nakamura,Yo-ichi Nabeshima,David B. Teplow,Masakataka Kinjo,Minako Hoshi,Minako Hoshi +24 more
TL;DR: A highly sensitive in vitro monitoring method using fluorescence correlation spectroscopy (FCS) combined with transmission electron microscopy (TEM) and toxicity assays should facilitate identifying Aβ assembly steps at which inhibition may be beneficial.
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An adaptive approach for uniform scanning in multifocal multiphoton microscopy with a spatial light modulator
Naoya Matsumoto,Shigetoshi Okazaki,Yasuko Fukushi,Hisayoshi Takamoto,Takashi Inoue,Susumu Terakawa +5 more
TL;DR: The MFS excitation method iteratively updates a computer-generated hologram (CGH) using correction coefficients to improve the fluorescence intensity distribution in a dye solution whose consistency is uniform.
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Evaluation of Drug Crystallinity in Aqueous Suspension Using Terahertz Time‐Domain Attenuated Total Reflection Spectroscopy
Gen Takebe,Yoichi Kawada,Koichiro Akiyama,Hironori Takahashi,Hisayoshi Takamoto,Mitsuo Hiramatsu +5 more
TL;DR: This study directly measured the crystallinity of a drug suspended in water, using a terahertz pulsed attenuated total reflection (ATR) method, and suggests the possibility of using this method for qualitative and quantitative assessments of crystalline drugs in suspension.
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Nanonization of poorly water-soluble drug clobetasone butyrate by using femtosecond laser
Sunqiang Pan,Gen Takebe,Masumi Suzuki,Hisayoshi Takamoto,Jianhong Ge,Chong Liu,Mitsuo Hiramatsu +6 more
TL;DR: In this article, a pulsewidth-tunable femtosecond laser was used to produce nanoparticles of clobetasone butyrate using poloxamer 188 as stabilizing agent.
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Urinary fluorescent metabolite O-aminohippuric acid is a useful biomarker for lung cancer detection.
Kazuhito Funai,Katsu Honzawa,Masako Suzuki,Shigeru Momiki,Katsuyuki Asai,Norio Kasamatsu,Akikazu Kawase,Tomomi Shinke,Hiroyuki Okada,Sadahiko Nishizawa,Hisayoshi Takamoto +10 more
TL;DR: A robust predictive biomarker for lung cancer was selected by the multivariate logistic analysis of fluorescent metabolites and identified to be O-aminohippuric acid (OAH), which exceeds the AUC of lung cancer detection by Amino index cancer screening, can be analyzed non-invasively without additional sample processing, and may be a valuable addition to existing lung cancer prediction models.