The action of sedatives on brain stem oculomotor systems in man.

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

The Pharmacology of Sedative/Hypnotics, Alcohol, and Anesthetics: Sites and Mechanisms of Action

Action of drugs on the electrical activity of the red nucleus.

Nitrazepam and diazepam only cause significant depression of respiratory rate and loss or righting reflex, in mice, at lethal doses. In sub-lethal doses they induce a stage of deep but rousable sleep which is quite distinct from the intermittent dozing of control mice and the comatose state of mice injected with pentobarbitone. However, the respiratory effects of nitrazepam and diazepam in high doses in mice and low doses in rabbits are modified by the presence of solvent. Furthermore the solvent itself causes a loss of righting reflex in mice and the lethal dose of nitrazepam and diazepam is greatly reduced when the drugs are administered in solvent

Holm E

Papers

Electrophysiological studies on the action of Mogadon on central nervous structures of the cat. A comparison with pentobarbital.