Hong-Yuan Lian

TL;DR: In this article, a statistical design with an L8 orthogonal array was adopted to optimize the synthetic conditions of mesoporous silica nanoparticles (MSNs) with respect to particle size and structural properties.

TL;DR: Wu et al. as discussed by the authors prepared nanoporous carbon (NC) particles of approx-imately 50nm diameter by direct carbonization of metal-organic frameworks (MOFs) and obtained MOF-derived NC(MOF-NC), which exhibit very high biocompatibility and are promising as intracellular drug delivery carriers.

TL;DR: Highly biocompatible coordination polymer (Prussian Blue) nanoparticles with a hollow interior and a microporous framework (denoted as HPB) are utilized as an anticancer drug capsule for chemotherapy of bladder cancer T24 cells.

Abstract: The load/release behaviors of a fluorescent molecule, fluorescein isothiocyanate (FITC), using mesoporous silica thin films as hosts are investigated through a hierarchical study of three parameters (i.e., loading methods, porous structures, and morphologies) from microscopic to macroscopic levels. Three different methods, physical adsorption (AD), entrapment (EN), and cleavable binding (CB), were used to load FITC into three-dimensional hexagonal (3DH) mesoporous silica thin films. On the basis of the results of fluorescence spectroscopies, we found a diffusion-controlled release (first-order release) for the AD-3DH case, a dissolution-controlled release (zero-order release) for the EN-3DH case, and a stimuli-responsive release for the CB-3DH case. Mesoporous silica thin films with two kinds of mesostructures, two-dimensional hexagonal (2DH) and 3DH, were successfully synthesized. The adsorption and release kinetics, including the dissociation constant (Kd) and half-life value (t1/2), for the 2DH and 3DH...

TL;DR: In this article, the fluorescence switching properties of conjugated copolymers containing triphenylamine, fluorene, benzo[2,1,3]thiadiazole, and cyclic urea moieties were investigated.