H
Hongming Zhu
Researcher at University of Illinois at Chicago
Publications - 8
Citations - 1033
Hongming Zhu is an academic researcher from University of Illinois at Chicago. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 3 publications receiving 995 citations.
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Journal Article
A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents
Bey-Dih Chang,Eugenia V. Broude,Milos Dokmanovic,Hongming Zhu,Adam Ruth,Yongzhi Xuan,Eugene S. Kandel,Ekkehart Lausch,Konstantin Christov,Igor B. Roninson +9 more
TL;DR: SLP induction in breast carcinoma cells treated with retinoids in vitro or in vivo was found to correlate with permanent growth inhibition under the conditions of minimal cytotoxicity, suggesting that this response may be particularly important for the antiproliferative effect of differentiating agents.
Journal ArticleDOI
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs.
Bey-Dih Chang,Yongzhi Xuan,Eugenia V. Broude,Hongming Zhu,Brigitte Schott,Jing Fang,Igor B. Roninson +6 more
TL;DR: The results indicate that p53 and p21 act as positive regulators of senescence-like terminal proliferation arrest, but their function is neither sufficient nor absolutely required for this treatment response in tumor cells.
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Identification of promoter elements responsible for transcriptional inhibition of polo-like kinase 1 and topoisomerase IIalpha genes by p21(WAF1/CIP1/SDI1).
TL;DR: Results indicate that inhibition of cell division-associated genes by p21 is mediated by different but overlapping mechanisms, which are not a general consequence of cell cycle arrest.
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ALDH2 mutation results in excessive basal nitric oxide production and a delayed response to nitroglycerin
TL;DR: In this paper , the authors examined functional properties of induced pluripotent stem cell-derived CD144+ endothelial cells (iPSC-ECs) that expressed wildtype (WT) vs ALDH2+/− variant.
Proceedings ArticleDOI
2022-RA-830-ESGO Expression of COL5A2 in ovarian tumor microenvironment and its mechanism of promoting ovarian cancer
Hongming Zhu,Tianmin Xu +1 more
TL;DR: Wang et al. as discussed by the authors explored the underlying mechanisms of the effect of COL5A2 on cell proliferation, migration and invasion of ovarian cancer in vitro and in vivo, and they analyzed the expression of the collagen family and explored the mechanism of altered COL5a2 expression in ovarian tumor microenvironment.