H
Hongru Zhou
Researcher at University of Massachusetts Medical School
Publications - 4
Citations - 568
Hongru Zhou is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: RNA-Binding Protein FUS & Histone code. The author has an hindex of 3, co-authored 3 publications receiving 509 citations.
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Journal ArticleDOI
Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules.
Daryl A. Bosco,Nathan Lemay,Hae Kyung Ko,Hongru Zhou,Christopher J. Burke,Thomas J. Kwiatkowski,Peter C. Sapp,Diane McKenna-Yasek,Robert H. Brown,Lawrence J. Hayward +9 more
TL;DR: A novel ALS truncation mutant (R495X) is reported that leads to a relatively severe ALS clinical phenotype compared with FUS missense mutations, and a potential link between FUS mutations and cellular pathways involved in stress responses that may be relevant to altered motor neuron homeostasis in ALS is demonstrated.
Journal ArticleDOI
Targeted mutation of mouse skeletal muscle sodium channel produces myotonia and potassium-sensitive weakness
Lawrence J. Hayward,Joanna S. Kim,Ming Yang Lee,Hongru Zhou,Ji W. Kim,Kumudini Misra,Mohammad Salajegheh,Fen Fen Wu,Chie Matsuda,Valerie Reid,Didier Cros,Eric P. Hoffman,Jean Marc Renaud,Stephen C. Cannon,Robert H. Brown +14 more
TL;DR: It is demonstrated that expression of the Met1592ValNa+ channel in mouse muscle is sufficient to produce important features of HyperKPP, including myotonia, K+-sensitive paralysis, and susceptibility to delayed weakness during recovery from fatigue.
Journal ArticleDOI
Cytoplasmic sequestration of FUS/TLS associated with ALS alters histone marks through loss of nuclear protein arginine methyltransferase 1
Michael Tibshirani,Miranda L. Tradewell,Katie R. Mattina,Sandra Minotti,Wencheng Yang,Hongru Zhou,Michael J. Strong,Lawrence J. Hayward,Heather D. Durham +8 more
TL;DR: Evidence is provided for loss of PRMT1 function as a consequence of cytoplasmic accumulation of FUS in the pathogenesis of ALS, including changes in the histone code regulating gene transcription.
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Subdiaphragmatic bronchogenic cysts: Case series and literature review
TL;DR: A series of 19 patients diagnosed with subdiaphragmatic bronchogenic cysts histopathologically at a single institution in China from 2012 to 2021 were presented, with the prognosis generally favorable.