H
Hseuh Kung Lin
Researcher at University of Pennsylvania
Publications - 5
Citations - 516
Hseuh Kung Lin is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Reductase & Receptor. The author has an hindex of 5, co-authored 5 publications receiving 496 citations. Previous affiliations of Hseuh Kung Lin include University of Oklahoma Health Sciences Center.
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Journal Article
Isoform-specific Induction of a Human Aldo-Keto Reductase by Polycyclic Aromatic Hydrocarbons (PAHs), Electrophiles, and Oxidative Stress: Implications for the Alternative Pathway of PAH Activation Catalyzed by Human Dihydrodiol Dehydrogenase
TL;DR: Data suggest that, in contrast to the CYPs, induction of AKR1C member(s) by PAHs and other bifunctional inducers is mediated indirectly via an antioxidant response element rather than a xenobiotic response element.
Journal ArticleDOI
Aldo-keto reductase (AKR) 1C3: role in prostate disease and the development of specific inhibitors.
Trevor M. Penning,Stephan Steckelbroeck,David R. Bauman,Meredith W. Miller,Yi Jin,Donna M. Peehl,Kar-Ming Fung,Kar-Ming Fung,Hseuh Kung Lin +8 more
TL;DR: Aldo-keto reductases (AKR) of the 1A, 1B, 1C and 1D subfamilies are involved in the pre-receptor regulation of nuclear (steroid hormone and orphan) receptors by regulating the local concentrations of their lipophilic ligands.
Journal ArticleDOI
Structure-function aspects and inhibitor design of type 5 17β-hydroxysteroid dehydrogenase (AKR1C3)☆
Trevor M. Penning,Michael E. Burczynski,Joseph M. Jez,Hseuh Kung Lin,Haiching Ma,Margaret Moore,Kapila Ratnam,Nisha T. Palackal +7 more
TL;DR: It is predicted that AKR1C3 catalyzes an ordered bi bi mechanism, that the rate determining step is k(chem), and that an oxyanion prevails in the transition state, and steroidal-based inhibitors that compete with the steroid product would be desirable.
Journal ArticleDOI
Mammalian 3α-hydroxysteroid dehydrogenases
Trevor M. Penning,John E. Pawlowski,Brian P. Schlegel,Joseph M. Jez,Hseuh Kung Lin,Susan S. Hoog,Melanie J. Bennett,Mitchell Lewis +7 more
TL;DR: Molecular cloning indicates that mammalian 3α-HSDs belong to the aldo-keto reductase superfamily and that they are highly homologous proteins, and details regarding structure-function relationships, including catalysis and cofactor and steroid hormone recognition have been elucidated.
Journal Article
Cloning, sequencing, and functional analysis of the 5′-flanking region of the rat 3α-hydroxysteroid/dihydrodiol dehydrogenase gene
Hseuh Kung Lin,Trevor M. Penning +1 more
TL;DR: C cis-acting elements responsible for the constitutive expression of the rat 3 alpha-HSD/DD gene were located on the 5'-flanking region by transient transfection of reporter-gene constructs into human hepatoma cells (HepG2).