H
Hua Lin
Researcher at SRI International
Publications - 16
Citations - 1243
Hua Lin is an academic researcher from SRI International. The author has contributed to research in topics: Mass spectrometry & Biomarker discovery. The author has an hindex of 10, co-authored 16 publications receiving 1190 citations.
Papers
More filters
Journal ArticleDOI
Quantification of proteins and metabolites by mass spectrometry without isotopic labeling or spiked standards
Weixun Wang,Haihong Zhou,Hua Lin,Sushmita Mimi Roy,Thomas A. Shaler,Lander R. Hill,Scott M. Norton,Praveen Kumar,Markus Anderle,Christopher H. Becker +9 more
TL;DR: A new method is presented for quantifying proteomic and metabolomic profile data by liquid chromatography-mass spectrometry with electrospray ionization, which provides differential expression measurements and enables the discovery of biological markers (biomarkers).
Journal ArticleDOI
Single nucleotide polymorphism determination using primer extension and time-of-flight mass spectrometry.
Jia Li,John M. Butler,Yuping Tan,Hua Lin,Stephanie Royer,Lynne Ohler,Thomas A. Shaler,Joanna M. Hunter,Daniel J. Pollart,Joseph A. Monforte,Christopher H. Becker +10 more
TL;DR: It is demonstrated here that analysis of these genetic markers can now be performed routinely in a rapid, automated, and high‐throughput fashion using time‐of‐flight mass spectrometry and a primer extension assay with a novel cleavable primer.
Journal ArticleDOI
Quantifying reproducibility for differential proteomics: noise analysis for protein liquid chromatography-mass spectrometry of human serum
TL;DR: The results indicate that for processed LC-MS data a constant coefficient of variation is dominant for high intensities, whereas a model for low intensities explains Poisson-like variations.
Patent
Volatile matrices for matrix-assisted laser desorption/ionization mass spectrometry
TL;DR: In this article, a sample preparation method for volatilization and mass spectrometric analysis of nonvolatile high molecular weight molecules is disclosed for use as matrices in matrix-assisted laser desorption/ionization mass analyzer.
Journal ArticleDOI
Differential expression profiling of serum proteins and metabolites for biomarker discovery
TL;DR: A liquid chromatography-mass spectrometry proteomics and metabolomics platform is presented and quantitative differential expression profiling is applied to a clinical study comparing healthy individuals and rheumatoid arthritis patients.