Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

Advances in the development of new therapeutic agents targeting the NS3-4A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus.

Synthesis and antiviral activity of some new bis-1,3-thiazole derivatives.

Elaborate ligand-based pharmacophore exploration and QSAR analysis guide the synthesis of novel pyridinium-based potent β-secretase inhibitory leads

The conjugate addition of allyl cyanide (II) to α,β-unsaturated thioamides (I) is catalyzed by soft Lewis acid/hard Broensted base/hard Lewis base cooperation to give the adducts (III) or (VI), which undergo cyclization into isothiazoles such as (IV).

Asymmetric Synthesis of Isothiazoles through Cu Catalysis: Direct Catalytic Asymmetric Conjugate Addition of Allyl Cyanide to α,β‐Unsaturated Thioamides

Huaming Chen

Papers

Isothiazoles as active-site inhibitors of HCV NS5B polymerase