Hui-Fang Cao

TL;DR: Overexpression of p28/gankyrin in HCC plays an important role and contributes to the metastasis potential in the process of carcinogenesis and may become a specific biological tissue marker for the pathological diagnosis of HCC.

TL;DR: This study shows that the T7-system screening-based AdSiRNA can be used successfully to silence an oncogene and indicates that p28 GANK may serve as a novel therapeutic target for treating HCC.

TL;DR: PCP-2 can inhibit both the wild-type and constitutively active forms of β-catenin in activating target genes such as c-myc and a loss of its regulatory function may be an alternative mechanism for activating β- catenin signaling.

TL;DR: It is shown that PCP-2 was endogenously expressed at the cell surface and upregulated with increased cell density and was a negative regulator for cell migration, and interaction of PCp-2 with its substrate beta-catenin is involved in the process of cell-cell contact.

TL;DR: It is found that PTEN protein was significantly down-regulated in HCC tissues compared with paired para-carcinoma tissues, and the level of PTEN expression may be a potential adjuvant parameter in forecasting the progression and prognosis of HCC patients.