Molecular imprinting technology (MIT) concerns formation of selective sites in a polymer matrix with the memory of a template. Recently, molecularly imprinted polymers (MIPs) have aroused extensive attention and been widely applied in many fields, such as solid-phase extraction, chemical sensors and artificial antibodies owing to their desired selectivity, physical robustness, thermal stability, as well as low cost and easy preparation. With the rapid development of MIT as a research hotspot, it faces a number of challenges, involving biological macromolecule imprinting, heterogeneous binding sites, template leakage, incompatibility with aqueous media, low binding capacity and slow mass transfer, which restricts its applications in various aspects. This critical review briefly reviews the current status of MIT, particular emphasis on significant progresses of novel imprinting methods, some challenges and effective strategies for MIT, and highlighted applications of MIPs. Finally, some significant attempts in further developing MIT are also proposed (236 references).

http://ir.yic.ac.cn/bitstream/133337/4853/1/Recent%20advances%20in%20molecular%20imprinting%20technology%20current%20status%2c%20challenges%20and%20highlighted%20applications.pdf

Recent advances in molecular imprinting technology: current status, challenges and highlighted applications

Herein, we present a survey of the literature covering the development of molecular imprinting science and technology over the years 2004-2011. In total, 3779 references to the original papers, rev ...

Molecular imprinting science and technology: a survey of the literature for the years 2004-2011.

A simple and effective method was proposed to prepare uniform surface-imprinted nanoparticles. This strategy was carried out by introducing vinyl groups to the surface of silica beads by a one-step modification, followed by copolymerization of functional monomers via reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization. Owing to the intrinsic advantages of controlled/living polymerization and surface imprinting technology, the resultant RAFT surface-imprinted nano-sized polymers (RAFT-SINPs) demonstrated spherical shaped particles with excellent monodispersity, and improvements in imprinting efficiency and mass transfer in comparison to molecularly imprinted polymers (MIPs) prepared by traditional precipitation polymerization. Recoveries of 93.4% and 79.8% were achieved by one-step extraction when RAFT-SINPs were used for the preconcentration and selective separation of atrazine in spiked corn and lettuce samples, respectively. These results provided the possibility for the separation and enrichment of atrazine from complicated matrices by RAFT-SINPs.

http://ir.yic.ac.cn/bitstream/133337/4847/1/Molecularly%20imprinted%20core-shell%20nanoparticles%20for%20determination%20of%20trace%20atrazine%20by%20reversible%20addition-fragmentation%20chain%20transfer%20surface%20imprinting.pdf

Molecularly imprinted core-shell nanoparticles for determination of trace atrazine by reversible addition-fragmentation chain transfer surface imprinting

Surface-imprinted core–shell Au nanoparticles for selective detection of bisphenol A based on surface-enhanced Raman scattering

Preparation and evaluation of molecularly imprinted ionic liquids polymer as sorbent for on-line solid-phase extraction of chlorsulfuron in environmental water samples

Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs.

A preparation method of a diphenyl guanidine molecular imprint solid-phase extracting agent relates to a preparation method of solid-phase extracting agent; the invention aims at providing a preparation method of molecular imprint solid-phase extracting agent which can effectively extract diphenyl guanidine from an enriched environmental sample. The technical proposal of the invention has the key points that: (1) diphenyl guanidine, methacrylic acid and ethylene glycol dimethacrylate are blended with the mol ratio of 1:4:20; the diphenyl guanidine is firstly added into a chloroform for dissolving, then the methacrylic acid is added to act with the diphenyl guanidine completely, after that, the ethylene glycol dimethacrylate and an azoisobutyronitrile are added in sequence, and the solution is communicated with nitrogen by ultrasonic and heated up to 55-60 DEG C for polymerization reaction; (2) the block polymer is prepared into a granular polymer which is soxhlet extracted by 10% of glacial acetic acid/ methanol solution; (3) the soxhlet extract product is washed by methanol until the washing agent shows neutral, and the diphenyl guanidine molecular imprint solid-phase extracting agent of the invention is obtained after vacuum drying. The invention is used for extracting diphenyl guanidine from an enriched environmental sample.

Huili Shi

Papers

Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs.

Preparing method of diphenylguanidine molecular imprinting solid phase extractant