H
Huilin Yang
Researcher at Johns Hopkins University
Publications - 13
Citations - 38
Huilin Yang is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 5 publications receiving 7 citations.
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Journal ArticleDOI
Targeting cancer metastasis with antibody therapeutics.
TL;DR: There is a growing interest in engineering targeted therapeutics, such as antibody drugs, that inhibit various steps in the metastatic cascade as mentioned in this paper, such as invasion, intravasation, circulation, extravasation, and colonization.
Journal ArticleDOI
A split, conditionally active mimetic of IL-2 reduces the toxicity of systemic cytokine therapy
Alfredo Quijano-Rubio,Aladdin M. Bhuiyan,Huilin Yang,Isabel Leung,Elisa Bello,Lestat R. Ali,Kevin Zhangxu,Jilliane Perkins,Jung Ho Chun,Wentao Wang,Marc J. Lajoie,Rashmi Ravichandran,Yun-Huai Kuo,Stephanie K. Dougan,Stanley R. Riddell,Jamie B. Spangler,Michael Dougan,Daniel-Adriano Silva,D. Baker +18 more
TL;DR: In this article , the authors describe a strategy to reduce the dose-limiting toxicities of monomeric cytokines by designing two components that require colocalization for activity and that can be independently targeted to restrict activity to cells expressing two surface markers.
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Controlled Release of TGF-β3 for Effective Local Endogenous Repair in IDD Using Rat Model
Lifan Zhu,Yan-Jun Yang,ZhanJun Yan,Jincai Zeng,Fengbiao Weng,Yuhui Shi,Pengcheng Shen,Ling Liu,Huilin Yang +8 more
TL;DR: In this paper , an intelligent biodegradable nanoplatform using hollow manganese dioxide (H-MnO2) was developed to modulate the degenerative microenvironment and release transforming growth factor beta-3 (TGF-β3), which may achieve good long-term therapeutic effects on needle puncture-induced intervertebral disc (IVD) degeneration.
Journal ArticleDOI
Engineered bispecific antibodies targeting the interleukin-6 and -8 receptors potently inhibit cancer cell migration and tumor metastasis.
Huilin Yang,Michelle Karl,Wentao Wang,Bartholomew Augustus Starich,Haosheng Tan,Ashley Kiemen,Alexandra B. Pucsek,Yun-Huai Kuo,Gabriella Russo,Tim Pan,Elizabeth M. Jaffee,Elana J. Fertig,Denis Wirtz,Jamie B. Spangler +13 more
TL;DR: In this paper , a bispecific antibody design was proposed to target the IL-6 and IL-8 receptors to concurrently block the signaling activity of both ligands, which can be readily combined with standard-of-care anti-proliferative drugs to develop effective anti-cancer regimens.