I
I. Molano
Researcher at University of Extremadura
Publications - 4
Citations - 468
I. Molano is an academic researcher from University of Extremadura. The author has contributed to research in topics: Arginase & Leishmania. The author has an hindex of 4, co-authored 4 publications receiving 438 citations.
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Journal ArticleDOI
Arginase I induction in macrophages, triggered by Th2-type cytokines, supports the growth of intracellular Leishmania parasites.
Virginia Iniesta,L. Carlos Gómez-Nieto,I. Molano,Alicia Mohedano,Jesualdo Carcelén,Cristina Mirón,Carlos Alonso,Inés Corraliza +7 more
TL;DR: A strong correlation exist between the permissibility of host cells to L. major infection and the induction of arginase I in macrophages, which might be a contributor to susceptibility in leishmaniasis.
Journal ArticleDOI
Arginase I induction during Leishmania major infection mediates the development of disease.
Virginia Iniesta,Jesualdo Carcelén,I. Molano,Pablo M. Peixoto,Eloy Redondo,Pilar Parra,Marina Mangas,Isabel Monroy,Maria Luisa Campo,C.G. Nieto,Inés Corraliza +10 more
TL;DR: Results show that arginase I is induced in both susceptible and resistant mice during the development of the disease, however, in BALB/c-infected tissues, the induction of this protein parallels the time of infection, while in C57BL/6 mice, the enzyme is upregulated only during footpad swelling.
Journal ArticleDOI
A Leishmania infantum multi-component antigenic protein mixed with live BCG confers protection to dogs experimentally infected with L. infantum.
I. Molano,M. García Alonso,C. Mirón,Eloy Redondo,Jose M. Requena,Manuel Soto,C.Gómez Nieto,C. Alonso +7 more
TL;DR: The data showed that after i.v. administration of 500,000 parasites of the L. infantum M/CAN/ES/96/BCN150 strain, zymodeme MON-1, the animals became infected as suggested by the humoral response against the parasite antigens, but the immunized dogs were not only normal at the clinical but also at the anatomo-pathological level.
Journal ArticleDOI
Meningeal leishmaniosis induced by Leishmania infantum in naturally infected dogs.
J. Viñuelas,M. Garcia-Alonso,L. Ferrando,I. Navarrete,I. Molano,C. Mirón,Jesualdo Carcelén,C. Alonso,C.G. Nieto +8 more
TL;DR: The immunological study of the cerebrospinal fluid of both animals showed that a large number of protein bands were recognized by those fluids and that they were similar to the ones recognized by the sera from the same animals.