I
Ian G. Macara
Researcher at University of Sheffield
Publications - 6
Citations - 521
Ian G. Macara is an academic researcher from University of Sheffield. The author has contributed to research in topics: Ferritin & Binding site. The author has an hindex of 6, co-authored 6 publications receiving 509 citations.
Papers
More filters
Journal ArticleDOI
The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake
TL;DR: Ferritin can be regarded as an enzyme to which the product remains firmly attached and the reconstituted ferritin was shown by several physical methods to be similar to natural Ferritin.
Journal ArticleDOI
Ferritin iron uptake and release. Structure-function relationships.
TL;DR: Iron uptake and release by ferritin molecules of different iron contents show similar profiles and it is concluded that the second model accounts better for the experimental results presented now and in previous publications.
Journal ArticleDOI
The formation of ferritin from apoferritin. Inhibition and metal ion-binding studies
TL;DR: Inhibition by Zn(2+) of iron uptake by apoferritin at very low substrate concentrations is shown to be competitive and interpretation of titration data suggests there are two independent classes of binding site for Zn (2+) and several other cations.
Journal ArticleDOI
The formation of ferritin from apoferritin. Catalytic action of apoferritin.
TL;DR: Experimental evidence indicates that apoferritin binds ferrous iron and catalyses the initial stage in the formation of the ferric oxide hydrate inside the protein shell, which involves the oxidation of sufficient iron within the protein molecule to form a stable nucleus on which the growth of the microcrystalline iron-core particles can proceed.
Journal ArticleDOI
The release of iron from horse spleen ferritin to 1,10-phenanthroline
TL;DR: The rate of release of iron to 1,10-phenanthroline from ferritin fractions of different iron contents has been studied and initial rates of release did not correlate significantly with protein concentration.