Showing papers by "Ichiro Ono published in 2002"

Therapeutic effect of using a long-pulsed alexandrite laser system with a cooling device for epilation in reconstructive surgery of auricular malformations.

Abstract: Hair growth after reconstructive surgery for auricular malformations including microtia and full-thickness skin grafts poses serious problems for patients. Currently, the author and his colleagues use a long-pulsed alexandrite laser system with a cooling device to remove hair from hairy regions before and after reconstructive surgery of auricular malformations. They achieve good results with approximately two to five treatments, and report the details here. Using their protocols there were no adverse reactions such as ulceration, scarring, pigmentation, or depigmentation. The use of this system may change the technique of auricle treatment because of the advantages it offers, such as low invasiveness, high effectiveness, and safety.

A comparison of the shapes of hydroxyapatite implants before and after implantation.

Abstract: Based on helical volume scan computed tomography (HVCT) data, it has been demonstrated previously that real-size models can be prepared with the binder-jet method with extremely high precision of various parts ranging from the outer structure of the cranio-maxillofacial bone to such fine parts as the cranial base and the orbital walls. The application of this method to clinical cases with large cranial bone defects has also been studied. The results showed the usefulness of the binder-jet method, employing starch for fixing, with which a model can be prepared faster and with less deformity caused by the weight of the material itself. Therefore, the binder-jet method is expected to attain greater clinical significance in this field.In this study the comparison between the shapes of implants before and after implantation revealed that the most important aspect of the design of hydroxyapatite (HAP) implants was determining the shapes of edges, especially its angles. That is, an implant needs very little trimming before being implanted to the patient's defective site if the shape of the edges of the implant can be designed and prepared to fix the incised bone surfaces properly. In addition, to obtain optimum results it was also shown that it is necessary to design optimal shapes of implants, taking into account thickness, porosity, and curvature, before processing the shapes of edges. It was found necessary to establish a technology and a method for producing HAP implants that perfectly fit cranial bone defects. For this purpose, it would be useful to make a template of the implants using the mirror-reversion and binder-jet methods. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res (Appl Biomater) 63: 312–318, 2002

Agent for anagenesis

Abstract: PROBLEM TO BE SOLVED: To provide a new agent for anagenesis. SOLUTION: The agent for anagenesis comprises a combination of a Hepatocyte growth factor and a basic fibroblast growth factor, and an agent for suppressing scar formation of a wounded part using the Hepatocyte growth factor as an active component. The Hepatocyte growth factor is preferably administered as a gene. The combined agent includes a mode in which the basic fibroblast growth factor acts to express at first. COPYRIGHT: (C)2004,JPO

Osteogenic treatment device

Abstract: PROBLEM TO BE SOLVED: To provide an osteogenic treatment device having excellent osteogenesis ability. SOLUTION: This osteogenic treatment device comprises a nucleic acid containing a base sequence encoding a bone morphogenetic protein (BMP), a vector and a substrate body and is transplanted in a living body to carry out osteogenic treatment. The bone morphogenetic protein is preferably BMP-2 and the nucleic acid preferably contains an expression plasmid derived base sequence. The vector is preferably a positively charged liposome being a vector derived from a nonvirus. The form of its substrate body is preferably a block body, especially a porous body having 30-95% porosity. The constituent material of the substrate body is a material consisting essentially of hydroxyapatite or tricalcium phosphate. COPYRIGHT: (C)2004,JPO

Verfahren zum Herstellen eines Implantats

Abstract: In einem Verfahren zum Erzeugen eines Implantats wird (a) eine aus einem Pulver bestehende Schicht vorbestimmter Dicke ausgebildet und (b) entsprechend der gewunschten Form des Implantats eine reagierende Flussigkeit auf diese Schicht aufgebracht, wobei die mit der Flussigkeit reagierenden Bereiche der Schicht gehartet werden. Diese Schritte werden wiederholt, um mehrere, gehartete Bereiche aufweisende Schichten ubereinander zu stapeln. Die ubereinander gestapelten geharteten Bereiche der aus dem Pulver bestehenden Schichten bilden so ein dreidimensionales Implantat. Das Pulver enthalt a-Tricalciumphosphat und/oder Tetracalciumphosphat. Das Ca/P-Verhaltnis des Pulvers liegt in einem Bereich von 1,40 bis 2,0.

Implant forming method e.g. artificial skull bone involves forming layer of ingredient powder, applying reactant liquid to layer to harden specific portions

Abstract: The invention relates to a method for forming an implant having a desired shape. A layer of powder of ingredients of predetermined thickness is formed, and a reaction liquid is applied to the layer according to the desired shape of the implant. for curing parts of the ingredient powder, the above steps being repeated for stacking a plurality of layers. The ingredient powder is a powder comprising at least ingredients consisting of alpha-tricalcium phosphate and tetracalcium phosphate, with a Ca / P ratio in the range of 1.40 to 2.0.0. APPLICATION: Production of an implant complex in shape with a high degree of precision and faster.