Showing papers by "Ilker Tasci published in 2023"
TL;DR: A searchable abstracts of presentations at key conferences in endocrinology can be found in this paper , where the abstracts are extracted from the corresponding abstracts from the conference proceedings.
Abstract: Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
TL;DR: In this paper , the authors performed a study using the Turkish Ministry of Health's national electronic health records involving 83,063,515 citizens as of December 2021 dating back 2016.
TL;DR: In this article , the authors explored the prevalence of geriatric syndromes and comorbid conditions, as well as their interrelationships, in individuals aged 90 years and over.
Abstract: OBJECTIVE
The aim of this study was to explore the prevalence of geriatric syndromes and comorbid conditions, as well as their interrelationships, in individuals aged 90 years and over.
METHODS
This study included participants aged 90 years and older who underwent a comprehensive geriatric assessment in a tertiary geriatric outpatient clinic. Demographic and clinical characteristics were obtained using the electronic medical records. The geriatric syndrome burden was calculated by adding each syndrome, which was then stratified into one of two groups based on the median value: no or low burden (<4) and high burden (≥4). The modified Charlson comorbidity index was used to determine chronic disease burden.
RESULTS
A total of 235 participants (93.2 ± 2.7 years) were recruited in this study. The mean index score was 7.3, and 46% (n = 107) of participants had a high geriatric syndrome burden. The most common geriatric syndrome was incontinence (69%), followed by polypharmacy (60%) and depression (43%). When compared to patients without such a diagnosis, the prevalence of polypharmacy was significantly higher in patients diagnosed with hypertension, chronic kidney disease, cardiovascular disease, diabetes mellitus and chronic obstructive pulmonary disease (p = 0.02, p = 0.02, p < 0.001, p = 0.008, p = 0.007, respectively). However, no chronic disease was associated with geriatric syndrome burden.
CONCLUSIONS
We found that the burden of medical conditions in the older population over 90 years of age could influence general health status significantly, with a high prevalence of chronic diseases and geriatric syndromes.
TL;DR: Wang et al. as discussed by the authors found a higher MCR prevalence in women than men and a more significant relationship between depression and motor cognitive risk syndrome (MCR) in female participants.
Abstract: In a recent issue of the European Journal of Neurology, Xu et al. [1] demonstrated an association of depression with motoric cognitive risk syndrome (MCR) in a large sample of Chinese older adults, even after controlling for potential covariates. The authors also found a higher MCR prevalence in women than men and a more significant relationship between depression and MCR in female participants. By performing a longitudinal analysis, this study further strengthens the evidence for the development of MCR among older individuals with depression. This study provides novel implications for the role of depressed mood and gender differences in MCR, possibly increasing the risk of later development of dementia. We would like to draw attention to a few points worth discussing. The authors may not have considered a few important factors that may have influenced their results, such as adiposity and lifestyle. These clinical measurements were reportedly collected in the China Health and Retirement Longitudinal Study (CHARLS), whose data were used in this study [2]. Being overweight, assessed according to body mass index (BMI), poses greater risk for the central nervous system, particularly cognitive functioning. Obesity in middle age is an important risk factor for cognitive impairment and dementia. MCR is a preclinical phase of dementia, particularly Alzheimer's disease and vascular dementia [3]. Higher BMI and waist circumference have been reported to increase the risk of MCR in a nationally representative cohort study involving 4915 individuals [3]. These results support the contribution of adipocytemediated inflammation to the development of MCR in middleaged and older populations. Physical activity can prevent or help manage chronic diseases, such as hypertension, diabetes mellitus, stroke and coronary heart disease. Exercise is also associated with reduced morbidity and mortality in older adults as well as improved mental wellbeing. In a populationbased study evaluating the association of physical activity with subsequent dementiarelated magnetic resonance imaging changes, healthy gray matter and total brain volume were identified in older adults who actively participated in physical activity during middle adulthood after an average of 21 years [4]. Physical activity that maintains general fitness and health is an absolute to prevent declines in gross motor skills, fine motor coordination, and bodily movement, resulting in skeletal energy expenditure [5]. Enhanced physical activity has an ameliorating effect on neuronal morphology and physiology, interaction of neuronal and vascular networks, axon growth, and synaptic function [5]. Thus, there appears to be an interaction in older adults participating in physical activity not only with an increase in muscle strength but also with a large improvement in cognitivemotor function. In conclusion, providing data on BMI and physical activity status may make the results more robust, which may be beneficial for clinical practice. Adjusting for these covariates in the risk prediction model for MCR could allow us to better understand the independent effects of depression. This new evidence would further add to the value of this study, which aims to understand the relationship between depression and MCR among communitydwelling older adults.