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Ivan Leo Pinto
Researcher at GlaxoSmithKline
Publications - 66
Citations - 1551
Ivan Leo Pinto is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Cromakalim & Phospholipase A2. The author has an hindex of 24, co-authored 66 publications receiving 1516 citations. Previous affiliations of Ivan Leo Pinto include University of Manchester.
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The peroxisome proliferator-activated receptor delta promotes lipid accumulation in human macrophages.
Helen Vosper,Lisa Patel,Tracey L. Graham,Guennadi A. Khoudoli,Alexander Hill,Colin H. Macphee,Ivan Leo Pinto,Stephen A. Smith,Keith E. Suckling,C. Roland Wolf,Colin N. A. Palmer +10 more
TL;DR: Data suggest that PPARδ may play a role in the pathology of diseases associated with lipid-filled macrophages, such as atherosclerosis, arthritis, and neurodegeneration.
Journal ArticleDOI
The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2.
Josie A. Blackie,Jackie C. Bloomer,Murray J. B. Brown,Hung Yuan Cheng,Beverley Hammond,Deirdre Mary Bernadette Hickey,Robert J. Ife,Colin A. Leach,V.Ann Lewis,Colin H. Macphee,Kevin J. Milliner,Kitty Moores,Ivan Leo Pinto,Stephen A. Smith,Ian Stansfield,Steven J. Stanway,Maxine A. Taylor,Colin J. Theobald +17 more
TL;DR: Cyclopentyl fused derivative 21, SB-480848, showed an enhanced in vitro and in vivo profile versus SB-435495 and has been selected for progression to man.
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Inhibition of herpes proteases and antiviral activity of 2-substituted thieno[2,3-d]oxazinones.
Richard L. Jarvest,Ivan Leo Pinto,S M Ashman,Christine E. Dabrowski,A V Fernandez,L J Jennings,Patrick Lavery,David G. Tew +7 more
TL;DR: Cinnamyl derivatives of thieno[2,3-d]oxazinones are mechanism-based inhibitors of the HSV-2, VZV and CMV herpes proteases which demonstrate nanomolar potency.
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Non thiazolidinedione antihyperglycaemic agents. 1: α-Heteroatom substituted β-phenylpropanoic acids
Derek R. Buckle,Barrie C. C. Cantello,Michael A. Cawthorne,P.J. Coyle,David Kenneth Dean,Andrew Faller,David Haigh,Richard Mark Hindley,L. J. Jefcott,Carolyn A. Lister,Ivan Leo Pinto,Harshad Kantilal Rami,D.G. Smith,Stephen A. Smith +13 more
TL;DR: The 5-benzylthiazolidine-2,4-dione moiety of insulin sensitising antidiabetic agents can be replaced by a range of α-heteroatom functionalised β-phenylpropanoic acids as discussed by the authors.
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The synthesis of 5-alkoxy and 5-amino substituted thiophenes
TL;DR: In this paper, 5-Alkoxythiophenes have been prepared by an extension of the Gewald thiophene synthesis and a novel four component condensation reaction uncovered by which 5-aminothiophenses were prepared.