J
J. Douglas Bremner
Researcher at Emory University
Publications - 322
Citations - 38092
J. Douglas Bremner is an academic researcher from Emory University. The author has contributed to research in topics: Coronary artery disease & Medicine. The author has an hindex of 89, co-authored 287 publications receiving 34746 citations. Previous affiliations of J. Douglas Bremner include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
The enduring effects of abuse and related adverse experiences in childhood: A convergence of evidence from neurobiology and epidemiology
Robert F. Anda,Vincent J. Felitti,J. Douglas Bremner,John D Walker,Charles L. Whitfield,Bruce D Perry,Shanta R. Dube,Wayne H. Giles +7 more
TL;DR: The graded relationship of the ACE score to 18 different outcomes in multiple domains theoretically parallels the cumulative exposure of the developing brain to the stress response with resulting impairment in multiple brain structures and functions.
Journal ArticleDOI
Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses.
John H. Krystal,Laurence P. Karper,John Seibyl,Glenna K. Freeman,Richard C. Delaney,J. Douglas Bremner,George R. Heninger,Malcolm B. Bowers,Dennis S. Charney +8 more
TL;DR: These data indicate that N-methyl-D-aspartate antagonists produce a broad range of symptoms, behaviors, and cognitive deficits that resemble aspects of endogenous psychoses, particularly schizophrenia and dissociative states.
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Hippocampal volume reduction in major depression.
J. Douglas Bremner,Meena Narayan,Eric R. Anderson,Lawrence H. Staib,Helen L. Miller,Dennis S. Charney +5 more
TL;DR: These findings are consistent with smaller left hippocampal volume in depression, and were significant after brain size, alcohol exposure, age, and education were controlled for.
Journal ArticleDOI
MRI-based measurement of hippocampal volume in patients with combat-related posttraumatic stress disorder.
J. Douglas Bremner,Penny Randall,Tammy Scott,Richard A. Bronen,John Seibyl,Steven M. Southwick,Richard C. Delaney,Gregory McCarthy,Dennis S. Charney,Robert B. Innis +9 more
TL;DR: A smaller right hippocampal volume in PTSD that is associated with functional deficits in verbal memory is consistent with high levels of cortisol associated with stress.
Journal ArticleDOI
Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse--a preliminary report.
J. Douglas Bremner,Penny Randall,Penny Randall,Eric Vermetten,Lawrence H. Staib,Richard A. Bronen,Carolyn M. Mazure,Sandi Capelli,Gregory McCarthy,Gregory McCarthy,Robert B. Innis,Robert B. Innis,Dennis S. Charney,Dennis S. Charney +13 more
TL;DR: It is suggested that a decrease in left hippocampal volume is associated with abuse-related PTSD.