J
J. Hanley-Hyde
Researcher at National Institutes of Health
Publications - 8
Citations - 1354
J. Hanley-Hyde is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & Cell cycle. The author has an hindex of 7, co-authored 8 publications receiving 1345 citations.
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Journal ArticleDOI
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores.
Marshall Plaut,Jacalyn H. Pierce,Cynthia J. Watson,J. Hanley-Hyde,Richard P. Nordan,William E. Paul +5 more
TL;DR: It is shown that cross-linkage of FcεRI on a series of non-transformed murine mast cell lines, or treatment of these cells with calcium ionophores, stimulates increased messenger RNA levels and secretion of a group of lymphokines classically produced by a subset of murine T cell lines (TH2cells).
Journal Article
c-Myc overexpression associated DHFR gene amplification in hamster, rat, mouse and human cell lines.
TL;DR: The notion that DHFR gene amplification as a consequence of c-Myc deregulation may occur in a variety of cell lines irrespective of their cell type and species origins is supported.
Journal ArticleDOI
Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.
Sabine Mai,Sabine Mai,J. Hanley-Hyde,G. Jonah Rainey,Theodore I. Kuschak,James T. Paul,Trevor D. Littlewood,Harald Mischak,Lisa M. Stevens,Darren W. Henderson,J. Frederic Mushinski +10 more
TL;DR: The data suggest that Myc-induced genomic instability may contribute to neoplasia by increasing the levels of a cell cycle-regulating protein, cyclin D2, via intrachromosomal amplification of its gene or generation of extrachROMosomal copies.
Journal ArticleDOI
Expression of murine cyclin B1 mRNAs and genetic mapping of related genomic sequences.
J. Hanley-Hyde,J. Frederic Mushinski,Moshe J. Sadofsky,Konrad Huppi,Marianne Krall,Christine A. Kozak,Beverly A. Mock +6 more
TL;DR: Through Southern blot analyses of DNA from backcross and cogenic mice, recombinant inbred strains, and somatic cell hybrids, the genetic loci that produce the cyclin B1-related sequences were mapped on mouse chromosomes 5, 1, 17, 4, 14, 13, 7, X, and 8, respectively.
Book ChapterDOI
Myc-induced cyclin D2 genomic instability in murine B cell neoplasms.
J F Mushinski,J. Hanley-Hyde,G. J. Rainey,G. J. Rainey,Theodore I. Kuschak,Cheryl Taylor,M. Fluri,L. M. Stevens,L. M. Stevens,Darren W. Henderson,Sabine Mai,Sabine Mai +11 more
TL;DR: The actions of the proto-oncogene, c-Myc, are considered, which may contribute to both steps of carcinogenesis, including B-cell neoplasia.